RNA regulation of epigenetic processes. Export

@article{citeulike:4745200, abstract = {There is increasing evidence that dynamic changes to chromatin, chromosomes and nuclear architecture are regulated by RNA signalling. Although the precise molecular mechanisms are not well understood, they appear to involve the differential recruitment of a hierarchy of generic chromatin modifying complexes and DNA methyltransferases to specific loci by RNAs during differentiation and development. A significant fraction of the genome-wide transcription of non-protein coding RNAs may be involved in this process, comprising a previously hidden layer of intermediary genetic information that underpins developmental ontogeny and the differences between species, ecotypes and individuals. It is also evident that RNA editing is a primary means by which hardwired genetic information in animals can be altered by environmental signals, especially in the brain, indicating a dynamic RNA-mediated interplay between the transcriptome, the environment and the epigenome. Moreover, RNA-directed regulatory processes may also transfer epigenetic information not only within cells but also between cells and organ systems, as well as across generations.}, address = {Australian Research Council Centre for Functional and Applied Genomics, Institute for Molecular Bioscience, the University of Queensland, St. Lucia, Australia; Institute for Brain Disorders and Neural Regeneration, Departments of Neurology, Neuroscience and Psychiatry and Behavioral Sciences, Einstein Cancer Center and Rose F. Kennedy Center for Research in Mental Retardation and Developmental Disabilities, Albert Einstein College of Medicine, Bronx, New York, NY, USA}, author = {Mattick, John S. and Amaral, Paulo P. and Dinger, Marcel E. and Mercer, Tim R. and Mehler, Mark F.}, citeulike-article-id = {4745200}, citeulike-linkout-0 = {http://dx.doi.org/10.1002/bies.080099}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19154003}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19154003}, citeulike-linkout-3 = {http://www3.interscience.wiley.com/cgi-bin/abstract/121641833/ABSTRACT}, doi = {10.1002/bies.080099}, issn = {1521-1878}, journal = {BioEssays : news and reviews in molecular, cellular and developmental biology}, keywords = {chromatin, chromosomes, environment, epigenetic, epigenome, gene-regulation, regulation, rna, rna-regulation, signals}, month = {January}, number = {1}, pages = {51--59}, posted-at = {2009-10-06 00:41:53}, priority = {4}, title = {RNA regulation of epigenetic processes.}, url = {http://dx.doi.org/10.1002/bies.080099}, volume = {31}, year = {2009} }

TY - JOUR ID - citeulike:4745200 L3 - citeulike-article-id:4745200 N2 - There is increasing evidence that dynamic changes to chromatin, chromosomes and nuclear architecture are regulated by RNA signalling. Although the precise molecular mechanisms are not well understood, they appear to involve the differential recruitment of a hierarchy of generic chromatin modifying complexes and DNA methyltransferases to specific loci by RNAs during differentiation and development. A significant fraction of the genome-wide transcription of non-protein coding RNAs may be involved in this process, comprising a previously hidden layer of intermediary genetic information that underpins developmental ontogeny and the differences between species, ecotypes and individuals. It is also evident that RNA editing is a primary means by which hardwired genetic information in animals can be altered by environmental signals, especially in the brain, indicating a dynamic RNA-mediated interplay between the transcriptome, the environment and the epigenome. Moreover, RNA-directed regulatory processes may also transfer epigenetic information not only within cells but also between cells and organ systems, as well as across generations. IS - 1 JF - BioEssays : news and reviews in molecular, cellular and developmental biology SN - 1521-1878 AD - Australian Research Council Centre for Functional and Applied Genomics, Institute for Molecular Bioscience, the University of Queensland, St. Lucia, Australia; Institute for Brain Disorders and Neural Regeneration, Departments of Neurology, Neuroscience and Psychiatry and Behavioral Sciences, Einstein Cancer Center and Rose F. Kennedy Center for Research in Mental Retardation and Developmental Disabilities, Albert Einstein College of Medicine, Bronx, New York, NY, USA EP - 59 TI - RNA regulation of epigenetic processes. VL - 31 SP - 51 KW - chromatin KW - chromosomes KW - environment KW - epigenetic KW - epigenome KW - gene-regulation KW - regulation KW - rna KW - rna-regulation KW - signals AU - Mattick, John AU - Amaral, Paulo AU - Dinger, Marcel AU - Mercer, Tim AU - Mehler, Mark PY - 2009/01// UR - http://dx.doi.org/10.1002/bies.080099 ER -