Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells Export

@article{citeulike:5095487, abstract = {The Wnt pathway has a central role in stem cell regulation. Gattinoni et al. now show that activation of the Wnt signaling cascade in naive CD8+ T cells blocks their differentiation into effector T cells and triggers instead a memory stem cell\&\#19;like phenotype. These T memory stem cells show enhanced antitumor efficacy in mice compared with other T cell subsets, arguing for their further evaluation in adoptive immunotherapies (pages 731\&\#19;732).}, author = {Gattinoni, Luca and Zhong, Xiao-Song and Palmer, Douglas C. and Ji, Yun and Hinrichs, Christian S. and Yu, Zhiya and Wrzesinski, Claudia and Boni, Andrea and Cassard, Lydie and Garvin, Lindsay M. and Paulos, Chrystal M. and Muranski, Pawel and Restifo, Nicholas P.}, citeulike-article-id = {5095487}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nm.1982}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nm.1982}, day = {14}, doi = {10.1038/nm.1982}, issn = {1078-8956}, journal = {Nat Med}, keywords = {cancer, differentiation, immunology, memory, pathway, stem-cells}, month = {July}, number = {7}, pages = {808--813}, posted-at = {2009-07-22 22:52:55}, priority = {2}, publisher = {Nature Publishing Group}, title = {Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells}, url = {http://dx.doi.org/10.1038/nm.1982}, volume = {15}, year = {2009} }

TY - JOUR ID - citeulike:5095487 L3 - citeulike-article-id:5095487 N2 - The Wnt pathway has a central role in stem cell regulation. Gattinoni et al. now show that activation of the Wnt signaling cascade in naive CD8+ T cells blocks their differentiation into effector T cells and triggers instead a memory stem celllike phenotype. These T memory stem cells show enhanced antitumor efficacy in mice compared with other T cell subsets, arguing for their further evaluation in adoptive immunotherapies (pages 731732). IS - 7 JF - Nat Med SN - 1078-8956 EP - 813 TI - Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells PB - Nature Publishing Group VL - 15 SP - 808 KW - cancer KW - differentiation KW - immunology KW - memory KW - pathway KW - stem-cells AU - Gattinoni, Luca AU - Zhong, Xiao-Song AU - Palmer, Douglas AU - Ji, Yun AU - Hinrichs, Christian AU - Yu, Zhiya AU - Wrzesinski, Claudia AU - Boni, Andrea AU - Cassard, Lydie AU - Garvin, Lindsay AU - Paulos, Chrystal AU - Muranski, Pawel AU - Restifo, Nicholas PY - 2009/07/14/ UR - http://dx.doi.org/10.1038/nm.1982 ER -