Applications of a rat multiple tissue gene expression data set. Export

@article{citeulike:976971, abstract = {With the sequencing and assembly of the rat genome comes the difficult task of assigning functions to genes. Tissue localization of gene expression gives some information about the potential role of a gene in physiology. Various examples of the utility of multiple tissue gene expression data sets are illustrated here. First, we highlight their use in finding genes that might play an important role in a particular tissue on the basis of exclusive expression in that tissue or coexpression with a gene or genes with known function. Second, we show how this data might be used to explain known phenotypic differences between strains. Third, we show how expression patterns of genes in a genomic interval might identify candidate genes in quantitative trait loci (QTL) mapping studies. Lastly, we show how multiple tissue and species data can help researchers prioritize follow up studies to microarray experiments. All of these applications of multiple tissue gene expression data sets will play a role in functionally annotating the rat genome.}, address = {Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, USA. walker@gnf.org}, author = {Walker, John R. and Su, Andrew I. and Self, David W. and Hogenesch, John B. and Lapp, Hilmar and Maier, Rainer and Hoyer, Daniel and Bilbe, Graeme}, citeulike-article-id = {976971}, citeulike-linkout-0 = {http://dx.doi.org/10.1101/gr.2161804}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/15060018}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=15060018}, doi = {10.1101/gr.2161804}, issn = {1088-9051}, journal = {Genome research}, keywords = {annotation, co-expression, functional-genomics, gene, gene-expression, microarray, phenotype, quantitative-trait-loci, rats, tissue-specific}, month = {April}, number = {4}, pages = {742--749}, posted-at = {2009-09-28 13:52:43}, priority = {3}, title = {Applications of a rat multiple tissue gene expression data set.}, url = {http://dx.doi.org/10.1101/gr.2161804}, volume = {14}, year = {2004} }

TY - JOUR ID - citeulike:976971 L3 - citeulike-article-id:976971 N2 - With the sequencing and assembly of the rat genome comes the difficult task of assigning functions to genes. Tissue localization of gene expression gives some information about the potential role of a gene in physiology. Various examples of the utility of multiple tissue gene expression data sets are illustrated here. First, we highlight their use in finding genes that might play an important role in a particular tissue on the basis of exclusive expression in that tissue or coexpression with a gene or genes with known function. Second, we show how this data might be used to explain known phenotypic differences between strains. Third, we show how expression patterns of genes in a genomic interval might identify candidate genes in quantitative trait loci (QTL) mapping studies. Lastly, we show how multiple tissue and species data can help researchers prioritize follow up studies to microarray experiments. All of these applications of multiple tissue gene expression data sets will play a role in functionally annotating the rat genome. IS - 4 JF - Genome research SN - 1088-9051 AD - Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, USA. walker@gnf.org EP - 749 TI - Applications of a rat multiple tissue gene expression data set. VL - 14 SP - 742 KW - annotation KW - co-expression KW - functional-genomics KW - gene KW - gene-expression KW - microarray KW - phenotype KW - quantitative-trait-loci KW - rats KW - tissue-specific AU - Walker, John AU - Su, Andrew AU - Self, David AU - Hogenesch, John AU - Lapp, Hilmar AU - Maier, Rainer AU - Hoyer, Daniel AU - Bilbe, Graeme PY - 2004/04// UR - http://dx.doi.org/10.1101/gr.2161804 ER -