Partial protection of seasonal trivalent inactivated vaccine against novel pandemic influenza A/H1N1 2009: case-control study in Mexico City Export

@article{citeulike:6086645, abstract = {Objective To evaluate the association of 2008-9 seasonal trivalent inactivated vaccine with cases of influenza A/H1N1 during the epidemic in Mexico. Design Frequency matched case-control study. Setting Specialty hospital in Mexico City, March to May 2009. Participants 60 patients with laboratory confirmed influenza A/H1N1 and 180 controls with other diseases (not influenza-like illness or pneumonia) living in Mexico City or the State of Mexico and matched for age and socioeconomic status. Main outcome measures Odds ratio and effectiveness of trivalent inactivated vaccine against influenza A/H1N1. Results Cases were more likely than controls to be admitted to hospital, undergo invasive mechanical ventilation, and die. Controls were more likely than cases to have chronic conditions that conferred a higher risk of influenza related complications. In the multivariate model, influenza A/H1N1 was independently associated with trivalent inactivated vaccine (odds ratio 0.27, 95\% confidence interval 0.11 to 0.66) and underlying conditions (0.15, 0.08 to 0.30). Vaccine effectiveness was 73\% (95\% confidence interval 34\% to 89\%). None of the eight vaccinated cases died. Conclusions Preliminary evidence suggests some protection from the 2008-9 trivalent inactivated vaccine against pandemic influenza A/H1N1 2009, particularly severe forms of the disease, diagnosed in a specialty hospital during the influenza epidemic in Mexico City. 10.1136/bmj.b3928}, author = {Garcia-Garcia, Lourdes and Valdespino-Gomez, Jose L. and Lazcano-Ponce, Eduardo and Jimenez-Corona, Aida and Higuera-Iglesias, Anjarath and Cruz-Hervert, Pablo and Cano-Arellano, Bulmaro and Garcia-Anaya, Antonio and Ferreira-Guerrero, Elizabeth and Baez-Saldana, Renata and Ferreyra-Reyes, Leticia and Ponce-de-Leon-Rosales, Samuel and Alpuche-Aranda, Celia and Rodriguez-Lopez, Mario H. and Perez-Padilla, Rogelio and Hernandez-Avila, Mauricio}, citeulike-article-id = {6086645}, citeulike-linkout-0 = {http://dx.doi.org/10.1136/bmj.b3928}, citeulike-linkout-1 = {http://www.bmj.com/content/339/oct06_2/b3928.abstract}, citeulike-linkout-2 = {http://www.bmj.com/content/339/oct06_2/b3928.full.pdf}, day = {6}, doi = {10.1136/bmj.b3928}, journal = {BMJ}, keywords = {h1n1, influenza\_nieuw, mexico, pandemie, vaccin}, month = {October}, number = {oct06\_2}, pages = {b3928+}, posted-at = {2009-11-08 21:06:51}, priority = {2}, title = {Partial protection of seasonal trivalent inactivated vaccine against novel pandemic influenza A/H1N1 2009: case-control study in Mexico City}, url = {http://dx.doi.org/10.1136/bmj.b3928}, volume = {339}, year = {2009} }

TY - JOUR ID - citeulike:6086645 L3 - citeulike-article-id:6086645 N2 - Objective To evaluate the association of 2008-9 seasonal trivalent inactivated vaccine with cases of influenza A/H1N1 during the epidemic in Mexico. Design Frequency matched case-control study. Setting Specialty hospital in Mexico City, March to May 2009. Participants 60 patients with laboratory confirmed influenza A/H1N1 and 180 controls with other diseases (not influenza-like illness or pneumonia) living in Mexico City or the State of Mexico and matched for age and socioeconomic status. Main outcome measures Odds ratio and effectiveness of trivalent inactivated vaccine against influenza A/H1N1. Results Cases were more likely than controls to be admitted to hospital, undergo invasive mechanical ventilation, and die. Controls were more likely than cases to have chronic conditions that conferred a higher risk of influenza related complications. In the multivariate model, influenza A/H1N1 was independently associated with trivalent inactivated vaccine (odds ratio 0.27, 95% confidence interval 0.11 to 0.66) and underlying conditions (0.15, 0.08 to 0.30). Vaccine effectiveness was 73% (95% confidence interval 34% to 89%). None of the eight vaccinated cases died. Conclusions Preliminary evidence suggests some protection from the 2008-9 trivalent inactivated vaccine against pandemic influenza A/H1N1 2009, particularly severe forms of the disease, diagnosed in a specialty hospital during the influenza epidemic in Mexico City. 10.1136/bmj.b3928 IS - oct06_2 JF - BMJ TI - Partial protection of seasonal trivalent inactivated vaccine against novel pandemic influenza A/H1N1 2009: case-control study in Mexico City VL - 339 SP - b3928 KW - h1n1 KW - influenza_nieuw KW - mexico KW - pandemie KW - vaccin AU - Garcia-Garcia, Lourdes AU - Valdespino-Gomez, Jose AU - Lazcano-Ponce, Eduardo AU - Jimenez-Corona, Aida AU - Higuera-Iglesias, Anjarath AU - Cruz-Hervert, Pablo AU - Cano-Arellano, Bulmaro AU - Garcia-Anaya, Antonio AU - Ferreira-Guerrero, Elizabeth AU - Baez-Saldana, Renata AU - Ferreyra-Reyes, Leticia AU - Ponce-de-Leon-Rosales, Samuel AU - Alpuche-Aranda, Celia AU - Rodriguez-Lopez, Mario AU - Perez-Padilla, Rogelio AU - Hernandez-Avila, Mauricio PY - 2009/10/06/ UR - http://dx.doi.org/10.1136/bmj.b3928 ER -