Cell growth and size homeostasis in proliferating animal cells. Export

@article{citeulike:5135053, abstract = {A long-standing question in biology is whether there is an intrinsic mechanism for coordinating growth and the cell cycle in metazoan cells. We examined cell size distributions in populations of lymphoblasts and applied a mathematical analysis to calculate how growth rates vary with both cell size and the cell cycle. Our results show that growth rate is size-dependent throughout the cell cycle. After initial growth suppression, there is a rapid increase in growth rate during the G1 phase, followed by a period of constant exponential growth. The probability of cell division varies independently with cell size and cell age. We conclude that proliferating mammalian cells have an intrinsic mechanism that maintains cell size.}, author = {Tzur, Amit and Kafri, Ran and LeBleu, Valerie S. and Lahav, Galit and Kirschner, Marc W.}, citeulike-article-id = {5135053}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1174294}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/325/5937/167}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19589995}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19589995}, day = {10}, doi = {10.1126/science.1174294}, issn = {1095-9203}, journal = {Science (New York, N.Y.)}, keywords = {ageing, cell\_cycle, cell\_size, growth\_rate, homeostasis, lymphocyte}, month = {July}, number = {5937}, pages = {167--171}, posted-at = {2009-07-15 19:39:47}, priority = {2}, title = {Cell growth and size homeostasis in proliferating animal cells.}, url = {http://dx.doi.org/10.1126/science.1174294}, volume = {325}, year = {2009} }

TY - JOUR ID - citeulike:5135053 L3 - citeulike-article-id:5135053 N2 - A long-standing question in biology is whether there is an intrinsic mechanism for coordinating growth and the cell cycle in metazoan cells. We examined cell size distributions in populations of lymphoblasts and applied a mathematical analysis to calculate how growth rates vary with both cell size and the cell cycle. Our results show that growth rate is size-dependent throughout the cell cycle. After initial growth suppression, there is a rapid increase in growth rate during the G1 phase, followed by a period of constant exponential growth. The probability of cell division varies independently with cell size and cell age. We conclude that proliferating mammalian cells have an intrinsic mechanism that maintains cell size. IS - 5937 JF - Science (New York, N.Y.) SN - 1095-9203 EP - 171 TI - Cell growth and size homeostasis in proliferating animal cells. VL - 325 SP - 167 KW - ageing KW - cell_cycle KW - cell_size KW - growth_rate KW - homeostasis KW - lymphocyte AU - Tzur, Amit AU - Kafri, Ran AU - LeBleu, Valerie AU - Lahav, Galit AU - Kirschner, Marc PY - 2009/07/10/ UR - http://dx.doi.org/10.1126/science.1174294 ER -