The natural history of pain in alcoholic chronic pancreatitis, , Export

@article{citeulike:665466, abstract = {Background \& Aims: The pain pattern of chronic pancreatitis (CP) and its surgical implications are discussed. The aim of this study was to (1) define typical pain patterns, (2) correlate pain patterns with the presumptive causes of the pain, and (3) compare the natural history of patients treated conservatively or surgically with respect to pain relief, pancreatic dysfunction, and clinical outcome. Methods: A cohort in this prospective long-term study included 207 patients with alcoholic CP (91 without and 116 with surgery for pain relief). A clinically based staging system was applied to characterize pain in the evolution from onset to end-stage CP. Results: Average duration of CP was 17 years. In early-stage CP, episodes of recurrent (acute) pancreatitis predominated. Chronic pain was typically associated with local complications (mainly pseudocysts, 84 of 155; 54\%), relieved definitely by a single (drainage) procedure in approximately two thirds of patients. Additional surgery was required for late pain recurrence in 39 patients (34\%), primarily symptomatic cholestasis (18 of 39; 46\%). All patients achieved complete pain relief in advanced CP. Conclusions: In our experience, relief of chronic pain regularly follows selective surgery tailored to the presumptive pain cause or occurs spontaneously in uncomplicated advanced CP.GASTROENTEROLOGY 1999;116:1132-1140}, author = {Ammann, Rudolf W. and Muellhaupt, Beat}, citeulike-article-id = {665466}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/S0016-5085(99)70016-8}, citeulike-linkout-1 = {http://www.sciencedirect.com/science/article/B6WFX-4HK01HW-J/2/3f8bd41e38c3e465be7152275b96c04a}, doi = {10.1016/S0016-5085(99)70016-8}, journal = {Gastroenterology}, keywords = {dor, pancreatite}, month = {May}, number = {5}, pages = {1132--1140}, posted-at = {2006-05-22 13:16:14}, priority = {2}, title = {The natural history of pain in alcoholic chronic pancreatitis, ,}, url = {http://dx.doi.org/10.1016/S0016-5085(99)70016-8}, volume = {116}, year = {1999} }

TY - JOUR ID - citeulike:665466 L3 - citeulike-article-id:665466 N2 - Background & Aims: The pain pattern of chronic pancreatitis (CP) and its surgical implications are discussed. The aim of this study was to (1) define typical pain patterns, (2) correlate pain patterns with the presumptive causes of the pain, and (3) compare the natural history of patients treated conservatively or surgically with respect to pain relief, pancreatic dysfunction, and clinical outcome. Methods: A cohort in this prospective long-term study included 207 patients with alcoholic CP (91 without and 116 with surgery for pain relief). A clinically based staging system was applied to characterize pain in the evolution from onset to end-stage CP. Results: Average duration of CP was 17 years. In early-stage CP, episodes of recurrent (acute) pancreatitis predominated. Chronic pain was typically associated with local complications (mainly pseudocysts, 84 of 155; 54%), relieved definitely by a single (drainage) procedure in approximately two thirds of patients. Additional surgery was required for late pain recurrence in 39 patients (34%), primarily symptomatic cholestasis (18 of 39; 46%). All patients achieved complete pain relief in advanced CP. Conclusions: In our experience, relief of chronic pain regularly follows selective surgery tailored to the presumptive pain cause or occurs spontaneously in uncomplicated advanced CP.GASTROENTEROLOGY 1999;116:1132-1140 IS - 5 JF - Gastroenterology EP - 1140 TI - The natural history of pain in alcoholic chronic pancreatitis, , VL - 116 SP - 1132 KW - dor KW - pancreatite AU - Ammann, Rudolf AU - Muellhaupt, Beat PY - 1999/05// UR - http://dx.doi.org/10.1016/S0016-5085(99)70016-8 ER -