Peroxisome proliferator-activated receptor gamma agonists in renal disease. Export

@article{citeulike:804575, abstract = {Type 2 diabetes is a well recognised cause of chronic renal failure (CRF). Only few oral antidiabetic drugs can be used for treating type 2 diabetes in patients with CRF. Among them are repaglinide, a rapid-acting prandial insulin releaser, and peroxisome proliferator-activated receptor gamma (PPARgamma) agonists, such as rosiglitazone and pioglitazone. These compounds are metabolised in the liver, therefore accumulation of the drug and the risk of severe and prolonged hypoglycaemia are minimised. PPARgamma receptors are expressed in many tissues including the kidney. Recently, numerous healthful effects of PPARgamma agonists on several aspects related to renal function have been increasingly reported. These drugs have shown to possess many advantageous anti-inflammatory, haemodynamic, vascular and metabolic effects. In the present paper we have reviewed the more recent experimental studies that evaluated these potential beneficial effects of PPARgamma agonists on renal function and revised the results of their utilisation in patients with different degrees of renal impairment, in dialysis patients, and in patients with diabetes mellitus after kidney transplantation. Finally, tolerability and safety profile of PPARgamma agonists in patients with reduced glomerular filtration rate are also analysed.}, address = {Department of Endocrinology, Hospital General, Segovia, Spain. piglesias@hgse.sacyl.es}, author = {Iglesias, P. and D\'{\i}ez, J. J.}, citeulike-article-id = {804575}, citeulike-linkout-0 = {http://dx.doi.org/10.1530/eje.1.02134}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16645006}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16645006}, doi = {10.1530/eje.1.02134}, issn = {0804-4643}, journal = {Eur J Endocrinol}, keywords = {doenca\_renal, ppar\_gama}, month = {May}, number = {5}, pages = {613--621}, posted-at = {2006-08-18 00:36:30}, priority = {2}, title = {Peroxisome proliferator-activated receptor gamma agonists in renal disease.}, url = {http://dx.doi.org/10.1530/eje.1.02134}, volume = {154}, year = {2006} }

TY - JOUR ID - citeulike:804575 L3 - citeulike-article-id:804575 N2 - Type 2 diabetes is a well recognised cause of chronic renal failure (CRF). Only few oral antidiabetic drugs can be used for treating type 2 diabetes in patients with CRF. Among them are repaglinide, a rapid-acting prandial insulin releaser, and peroxisome proliferator-activated receptor gamma (PPARgamma) agonists, such as rosiglitazone and pioglitazone. These compounds are metabolised in the liver, therefore accumulation of the drug and the risk of severe and prolonged hypoglycaemia are minimised. PPARgamma receptors are expressed in many tissues including the kidney. Recently, numerous healthful effects of PPARgamma agonists on several aspects related to renal function have been increasingly reported. These drugs have shown to possess many advantageous anti-inflammatory, haemodynamic, vascular and metabolic effects. In the present paper we have reviewed the more recent experimental studies that evaluated these potential beneficial effects of PPARgamma agonists on renal function and revised the results of their utilisation in patients with different degrees of renal impairment, in dialysis patients, and in patients with diabetes mellitus after kidney transplantation. Finally, tolerability and safety profile of PPARgamma agonists in patients with reduced glomerular filtration rate are also analysed. IS - 5 JF - Eur J Endocrinol SN - 0804-4643 AD - Department of Endocrinology, Hospital General, Segovia, Spain. piglesias@hgse.sacyl.es EP - 621 TI - Peroxisome proliferator-activated receptor gamma agonists in renal disease. VL - 154 SP - 613 KW - doenca_renal KW - ppar_gama AU - Iglesias, P AU - Díez, JJ PY - 2006/05// UR - http://dx.doi.org/10.1530/eje.1.02134 ER -