Interleukin-18 in patients with congestive heart failure: induction of atrial natriuretic peptide gene expression. Export

@article{citeulike:2822065, abstract = {Activated inflammatory responses appear to play a role in the development of congestive heart failure (CHF). We investigated interleukin-18 (IL-18), which is a cytokine synthesized by activated macrophage, changes in patients with CHF. We evaluated 11 Japanese patients with angina pectoris (n=4) or CHF (n=7). Blood was sampled immediately after admission and at 1, 2, 3, 6, and 9 hours after admission and then every 12 hours until 5 days after admission. Plasma IL-18 concentrations were measured by an enzyme-linked immunosorbent assay. Expression of atrial natriuretic peptide (ANP) mRNA and protein synthesis was examined in cardiac myocyte by stimulation of IL-18. Plasma IL-18 concentration was significantly higher in patients with CHF than in 15 healthy volunteers (51+/-21 pg/mL, and 28+11 pg/mL, respectively, P<0.05). Increased expression of ANP mRNA was demonstrated in IL-18 treated myocytes. Protein synthesis in myocytes was increased by IL-18 in a dose-dependent manner. Increased secretion of IL-18 is induced in patients with CHF and correlates with the severity of myocardial damage and dysfunction.}, address = {Second Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Japan.}, author = {Seta, Y. and Kanda, T. and Tanaka, T. and Arai, M. and Sekiguchi, K. and Yokoyama, T. and Kurimoto, M. and Tamura, J. and Kurabayashi, M.}, citeulike-article-id = {2822065}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/11758978}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=11758978}, issn = {1078-0297}, journal = {Research communications in molecular pathology and pharmacology}, keywords = {congestive-heart-failure, il-18}, number = {1-2}, pages = {87--95}, posted-at = {2008-05-22 05:23:14}, priority = {2}, title = {Interleukin-18 in patients with congestive heart failure: induction of atrial natriuretic peptide gene expression.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/11758978}, volume = {108}, year = {2000} }

TY - JOUR ID - citeulike:2822065 L3 - citeulike-article-id:2822065 N2 - Activated inflammatory responses appear to play a role in the development of congestive heart failure (CHF). We investigated interleukin-18 (IL-18), which is a cytokine synthesized by activated macrophage, changes in patients with CHF. We evaluated 11 Japanese patients with angina pectoris (n=4) or CHF (n=7). Blood was sampled immediately after admission and at 1, 2, 3, 6, and 9 hours after admission and then every 12 hours until 5 days after admission. Plasma IL-18 concentrations were measured by an enzyme-linked immunosorbent assay. Expression of atrial natriuretic peptide (ANP) mRNA and protein synthesis was examined in cardiac myocyte by stimulation of IL-18. Plasma IL-18 concentration was significantly higher in patients with CHF than in 15 healthy volunteers (51+/-21 pg/mL, and 28+11 pg/mL, respectively, P<0.05). Increased expression of ANP mRNA was demonstrated in IL-18 treated myocytes. Protein synthesis in myocytes was increased by IL-18 in a dose-dependent manner. Increased secretion of IL-18 is induced in patients with CHF and correlates with the severity of myocardial damage and dysfunction. IS - 1-2 JF - Research communications in molecular pathology and pharmacology SN - 1078-0297 AD - Second Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Japan. EP - 95 TI - Interleukin-18 in patients with congestive heart failure: induction of atrial natriuretic peptide gene expression. VL - 108 SP - 87 KW - congestive-heart-failure KW - il-18 AU - Seta, Y AU - Kanda, T AU - Tanaka, T AU - Arai, M AU - Sekiguchi, K AU - Yokoyama, T AU - Kurimoto, M AU - Tamura, J AU - Kurabayashi, M PY - 2000///g UR - http://view.ncbi.nlm.nih.gov/pubmed/11758978 ER -