Elevated plasma interleukin-18 is a marker of insulin-resistance in type 2 diabetic and non-diabetic humans. Export

@article{citeulike:2961797, abstract = {Elevated plasma IL-18 is present in several conditions sharing insulin-resistance as common trait, but the association with insulin-resistance per se is not established. Plasma/serum IL-6, IL-18, TNF-alpha, soluble TNF receptor II (sTNFR2), and C-reactive protein (CRP) were measured in 97 patients with type 2 diabetes (DM) and 84 non-diabetic controls (CON). The association with insulin-resistance-estimated using the homeostasis model assessment (HOMA-IR)-was analyzed using multivariate linear and logistic regression. Compared to CON, DM demonstrated higher plasma levels of IL-18 (P = 0.001), IL-6 (P < 0.001), sTNFR2 (P = 0.005), and CRP (P < 0.001), while TNF-alpha was lower (P = 0.017). Plasma IL-18 increased across HOMA-IR quartiles in both DM and CON, both with and without adjustment for confounders (all P < 0.05). In contrast, neither IL-6, TNF-alpha, sTNFR2, nor CRP was associated with HOMA-IR in CON when adjusting for confounders. Accordingly, 50\% increase of IL-18 corresponded to a marked increase of HOMA-IR in both DM and CON (DM: 26\%, P = 0.014; CON: 25\%, P = 0.003) after adjustment for confounders. Our results show that plasma IL-18 was associated with HOMA-IR independent of obesity and type 2 diabetes.}, address = {Centre of Inflammation and Metabolism, The Department of Infectious Diseases and The Copenhagen Muscle Research Centre, Rigshospitalet and The Faculty of Health Sciences, University of Copenhagen, DK-2100 Copenhagen, Denmark. cfischer@dadlnet.dk}, author = {Fischer, C. P. and Perstrup, L. B. and Berntsen, A. and Eskildsen, P. and Pedersen, B. K.}, citeulike-article-id = {2961797}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.clim.2005.07.008}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16112617}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16112617}, doi = {10.1016/j.clim.2005.07.008}, issn = {1521-6616}, journal = {Clinical immunology (Orlando, Fla.)}, keywords = {il-18, il18-review}, month = {November}, number = {2}, pages = {152--160}, posted-at = {2008-07-04 04:58:41}, priority = {2}, title = {Elevated plasma interleukin-18 is a marker of insulin-resistance in type 2 diabetic and non-diabetic humans.}, url = {http://dx.doi.org/10.1016/j.clim.2005.07.008}, volume = {117}, year = {2005} }

TY - JOUR ID - citeulike:2961797 L3 - citeulike-article-id:2961797 N2 - Elevated plasma IL-18 is present in several conditions sharing insulin-resistance as common trait, but the association with insulin-resistance per se is not established. Plasma/serum IL-6, IL-18, TNF-alpha, soluble TNF receptor II (sTNFR2), and C-reactive protein (CRP) were measured in 97 patients with type 2 diabetes (DM) and 84 non-diabetic controls (CON). The association with insulin-resistance-estimated using the homeostasis model assessment (HOMA-IR)-was analyzed using multivariate linear and logistic regression. Compared to CON, DM demonstrated higher plasma levels of IL-18 (P = 0.001), IL-6 (P < 0.001), sTNFR2 (P = 0.005), and CRP (P < 0.001), while TNF-alpha was lower (P = 0.017). Plasma IL-18 increased across HOMA-IR quartiles in both DM and CON, both with and without adjustment for confounders (all P < 0.05). In contrast, neither IL-6, TNF-alpha, sTNFR2, nor CRP was associated with HOMA-IR in CON when adjusting for confounders. Accordingly, 50% increase of IL-18 corresponded to a marked increase of HOMA-IR in both DM and CON (DM: 26%, P = 0.014; CON: 25%, P = 0.003) after adjustment for confounders. Our results show that plasma IL-18 was associated with HOMA-IR independent of obesity and type 2 diabetes. IS - 2 JF - Clinical immunology (Orlando, Fla.) SN - 1521-6616 AD - Centre of Inflammation and Metabolism, The Department of Infectious Diseases and The Copenhagen Muscle Research Centre, Rigshospitalet and The Faculty of Health Sciences, University of Copenhagen, DK-2100 Copenhagen, Denmark. cfischer@dadlnet.dk EP - 160 TI - Elevated plasma interleukin-18 is a marker of insulin-resistance in type 2 diabetic and non-diabetic humans. VL - 117 SP - 152 KW - il-18 KW - il18-review AU - Fischer, CP AU - Perstrup, LB AU - Berntsen, A AU - Eskildsen, P AU - Pedersen, BK PY - 2005/11// UR - http://dx.doi.org/10.1016/j.clim.2005.07.008 ER -