Elevated interleukin-18 levels are associated with the metabolic syndrome independent of obesity and insulin resistance. Export

@article{citeulike:2961801, abstract = {OBJECTIVE: Activated innate immunity is thought to be involved in the pathogenesis of metabolic syndrome and type 2 diabetes. Interleukin-18 (IL-18) is a pleiotropic proinflammatory cytokine with important regulatory functions in the innate immune response. We sought to determine whether an elevated IL-18 concentration was a risk predictor for metabolic syndrome in a community population independent of obesity and hyperinsulinemia. METHODS AND RESULTS: A representative general population, aged 27 to 77 years, without clinical diabetes was studied for clinical and biochemical risk factors for metabolic syndrome. Serum IL-18 concentration measured in 955 subjects correlated with metabolic syndrome traits including body mass index (BMI), waist circumference, triglyceride, high-density lipoprotein (inversely), and fasting glucose and insulin levels (all P<0.001). Mean IL-18 levels rose progressively with the increasing number of metabolic risk factors (ANOVA P<0.001). After adjusting for age, gender, BMI, and insulin levels, increasing IL-18 tertiles were associated with an odds ratio for metabolic syndrome of 1.0, 1.42, and 2.28, respectively (P trend=0.007). The graded risk relation was even stronger in nonobese subjects and not attenuated when adjusted for C-reactive protein and IL-6 levels. CONCLUSIONS: Our findings support the hypothesis that activation of IL-18 is involved in the pathogenesis of the metabolic syndrome.}, address = {Sir Charles Gairdner Hospital Campus of the Heart Research Institute of Western Australia, and School of Medicine and Pharmacology, University of Western Australia, Nedlands, Perth. jhung@cyllene.uwa.edu.au}, author = {Hung, J. and McQuillan, B. M. and Chapman, C. M. and Thompson, P. L. and Beilby, J. P.}, citeulike-article-id = {2961801}, citeulike-linkout-0 = {http://dx.doi.org/10.1161/01.ATV.0000163843.70369.12}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/15790931}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=15790931}, doi = {10.1161/01.ATV.0000163843.70369.12}, issn = {1524-4636}, journal = {Arteriosclerosis, thrombosis, and vascular biology}, keywords = {bmi, c-reactive-protein, il-18, il-6, il18-review, metabolic-syndrome}, month = {June}, number = {6}, pages = {1268--1273}, posted-at = {2008-07-04 05:00:29}, priority = {2}, title = {Elevated interleukin-18 levels are associated with the metabolic syndrome independent of obesity and insulin resistance.}, url = {http://dx.doi.org/10.1161/01.ATV.0000163843.70369.12}, volume = {25}, year = {2005} }

TY - JOUR ID - citeulike:2961801 L3 - citeulike-article-id:2961801 N2 - OBJECTIVE: Activated innate immunity is thought to be involved in the pathogenesis of metabolic syndrome and type 2 diabetes. Interleukin-18 (IL-18) is a pleiotropic proinflammatory cytokine with important regulatory functions in the innate immune response. We sought to determine whether an elevated IL-18 concentration was a risk predictor for metabolic syndrome in a community population independent of obesity and hyperinsulinemia. METHODS AND RESULTS: A representative general population, aged 27 to 77 years, without clinical diabetes was studied for clinical and biochemical risk factors for metabolic syndrome. Serum IL-18 concentration measured in 955 subjects correlated with metabolic syndrome traits including body mass index (BMI), waist circumference, triglyceride, high-density lipoprotein (inversely), and fasting glucose and insulin levels (all P<0.001). Mean IL-18 levels rose progressively with the increasing number of metabolic risk factors (ANOVA P<0.001). After adjusting for age, gender, BMI, and insulin levels, increasing IL-18 tertiles were associated with an odds ratio for metabolic syndrome of 1.0, 1.42, and 2.28, respectively (P trend=0.007). The graded risk relation was even stronger in nonobese subjects and not attenuated when adjusted for C-reactive protein and IL-6 levels. CONCLUSIONS: Our findings support the hypothesis that activation of IL-18 is involved in the pathogenesis of the metabolic syndrome. IS - 6 JF - Arteriosclerosis, thrombosis, and vascular biology SN - 1524-4636 AD - Sir Charles Gairdner Hospital Campus of the Heart Research Institute of Western Australia, and School of Medicine and Pharmacology, University of Western Australia, Nedlands, Perth. jhung@cyllene.uwa.edu.au EP - 1273 TI - Elevated interleukin-18 levels are associated with the metabolic syndrome independent of obesity and insulin resistance. VL - 25 SP - 1268 KW - bmi KW - c-reactive-protein KW - il-18 KW - il-6 KW - il18-review KW - metabolic-syndrome AU - Hung, J AU - McQuillan, BM AU - Chapman, CM AU - Thompson, PL AU - Beilby, JP PY - 2005/06// UR - http://dx.doi.org/10.1161/01.ATV.0000163843.70369.12 ER -