Extracellular Matrix Turnover and Inflammatory Markers Independently Predict Functional Status and Outcome in Chronic Heart Failure Export

@article{citeulike:3064261, abstract = {Background Inflammatory pathways may promote extracellular matrix (ECM) remodeling and chronic heart failure (CHF) progression. The relationship between markers of inflammation and of ECM remodeling, and their influence on functional status and outcomes has not been examined in a large cohort of CHF patients.Methods and Results We measured baseline blood serum collagen (amino-terminal propeptide of collagen III [PIIINP], metalloproteinase 1 [MMP-1], tissue inhibitor of metalloproteinase 1 [TIMP-1]), and inflammatory (high-sensitivity C-reactive protein [(hsCRP], interleukin [IL]-18, IL-10) markers in 1009 patients enrolled in the Research into Etanercept Cytokine Antagonism in Ventricular Dysfunction (RECOVER) trial. A positive correlation was detected between the 2 classes of markers (PIIINP to IL-18, MMP-1 and TIMP-1 to CRP, TIMP-1 to IL-18, MMP-1 to IL-10). In the adjusted multivariable model including all biomarkers, only PIIINP (P = .03) and MMP-1 (P = .048) were independent predictors of 6-minute walk test (6-MWT), whereas in another model including only inflammatory biomarkers, IL-18 was an independent predictor. PIIINP (P = .001) was the only biomarker independently associated with death and CHF hospitalization.Conclusions The independent associations of PIIINP and MMP-1 with 6-MWT and PIIINP with CHF morbi-mortality suggest that excessive ECM turnover may be associated with functional capacity deterioration and poor outcome.}, author = {Radauceanu, Anca and Ducki, Camille and Virion, Jean-Marc and Rossignol, Patrick and Mallat, Ziad and Mcmurray, John and Van Veldhuisen, Dirk J. and Tavazzi, Luigi and Mann, Douglas L. and Capiaumont-Vin, Josette and Li, Minjiang and Hanriot, Didier and Zannad, Faiez}, citeulike-article-id = {3064261}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.cardfail.2008.02.014}, citeulike-linkout-1 = {http://www.sciencedirect.com/science/article/B6WHG-4SM233S-P/1/02f39767ad0a4d90bf2f50046d10a38b}, doi = {10.1016/j.cardfail.2008.02.014}, journal = {Journal of Cardiac Failure}, keywords = {heart-failure, il-18, inflammation}, month = {August}, number = {6}, pages = {467--474}, posted-at = {2008-07-30 22:59:18}, priority = {2}, title = {Extracellular Matrix Turnover and Inflammatory Markers Independently Predict Functional Status and Outcome in Chronic Heart Failure}, url = {http://dx.doi.org/10.1016/j.cardfail.2008.02.014}, volume = {14}, year = {2008} }

TY - JOUR ID - citeulike:3064261 L3 - citeulike-article-id:3064261 N2 - Background Inflammatory pathways may promote extracellular matrix (ECM) remodeling and chronic heart failure (CHF) progression. The relationship between markers of inflammation and of ECM remodeling, and their influence on functional status and outcomes has not been examined in a large cohort of CHF patients.Methods and Results We measured baseline blood serum collagen (amino-terminal propeptide of collagen III [PIIINP], metalloproteinase 1 [MMP-1], tissue inhibitor of metalloproteinase 1 [TIMP-1]), and inflammatory (high-sensitivity C-reactive protein [(hsCRP], interleukin [IL]-18, IL-10) markers in 1009 patients enrolled in the Research into Etanercept Cytokine Antagonism in Ventricular Dysfunction (RECOVER) trial. A positive correlation was detected between the 2 classes of markers (PIIINP to IL-18, MMP-1 and TIMP-1 to CRP, TIMP-1 to IL-18, MMP-1 to IL-10). In the adjusted multivariable model including all biomarkers, only PIIINP (P = .03) and MMP-1 (P = .048) were independent predictors of 6-minute walk test (6-MWT), whereas in another model including only inflammatory biomarkers, IL-18 was an independent predictor. PIIINP (P = .001) was the only biomarker independently associated with death and CHF hospitalization.Conclusions The independent associations of PIIINP and MMP-1 with 6-MWT and PIIINP with CHF morbi-mortality suggest that excessive ECM turnover may be associated with functional capacity deterioration and poor outcome. IS - 6 JF - Journal of Cardiac Failure EP - 474 TI - Extracellular Matrix Turnover and Inflammatory Markers Independently Predict Functional Status and Outcome in Chronic Heart Failure VL - 14 SP - 467 KW - heart-failure KW - il-18 KW - inflammation AU - Radauceanu, Anca AU - Ducki, Camille AU - Virion, Jean-Marc AU - Rossignol, Patrick AU - Mallat, Ziad AU - Mcmurray, John AU - Van Veldhuisen, Dirk AU - Tavazzi, Luigi AU - Mann, Douglas AU - Capiaumont-Vin, Josette AU - Li, Minjiang AU - Hanriot, Didier AU - Zannad, Faiez PY - 2008/08// UR - http://dx.doi.org/10.1016/j.cardfail.2008.02.014 ER -