Circulating Pro- and Anti-inflammatory Cytokines in Polish Women with Gestational Diabetes.

@article{citeulike:3089929, abstract = {In this study we measured serum concentrations of proinflammatory interleukin-6, interleukin-8, and interleukin-18 as well as anti-inflammatory interleukin-10 in 30 pregnant women with normal glucose tolerance, in 32 women with abnormal results of a 50-g glucose challenge test, and in 57 patients with gestational diabetes mellitus. Patients with gestational diabetes had significantly higher IL-6 (median 1.0 [0.7-1.5] vs. 0.7 [0.4-0.8] pg/ml, p=0.001), IL-8 (2.1 [1.1-4.2] pg/ml vs. 0.7 [0.4-0.9] pg/ml, p<0.0001), and IL-18 (249.3 [188.5-318.7] pg/ml vs. 186.7 [139.9-243.9] pg/ml, p=0.005) as well as lower IL-10 levels than healthy pregnant women (0.6 [0.5-1.5] pg/ml vs. 2.9 [1.8-3.2] pg/ml, p<0.0001). After adjusting for glucose, insulin, and BMI values, the differences in IL-8 and IL-18 became insignificant, whereas the differences in IL-6 and IL-10 levels remained highly significant (p<0.0001). The subjects with abnormal glucose challenge test results had higher IL-6 levels (0.9 [0.7-1.3] pg/ml, p=0.005) and similar levels of other cytokines as compared with the women with normal glucose tolerance. Our results suggest an impaired balance between circulating pro- and anti-inflammatory cytokines in patients with gestational diabetes; however, a significant contribution of maternal obesity to the increased levels of IL-8 and IL-18 should be underlined.}, address = {1Department of Pathophysiology of Pregnancy, Medical University of Bialystok, Poland.}, author = {Kuzmicki, M and Telejko, B and Zonenberg, A and Szamatowicz, J and Kretowski, A and Nikolajuk, A and Laudanski, P and Gorska, M}, citeulike-article-id = {3089929}, doi = {10.1055/s-2008-1073166}, issn = {0018-5043}, journal = {Hormone and metabolic research. Hormon- und Stoffwechselforschung. Hormones et metabolisme}, keywords = {il-18, il-6, inflammation}, month = {April}, posted-at = {2008-08-06 06:10:03}, priority = {2}, title = {Circulating Pro- and Anti-inflammatory Cytokines in Polish Women with Gestational Diabetes.}, url = {http://dx.doi.org/10.1055/s-2008-1073166}, year = {2008} }

TY - JOUR ID - citeulike:3089929 L3 - citeulike-article-id:3089929 N2 - In this study we measured serum concentrations of proinflammatory interleukin-6, interleukin-8, and interleukin-18 as well as anti-inflammatory interleukin-10 in 30 pregnant women with normal glucose tolerance, in 32 women with abnormal results of a 50-g glucose challenge test, and in 57 patients with gestational diabetes mellitus. Patients with gestational diabetes had significantly higher IL-6 (median 1.0 [0.7-1.5] vs. 0.7 [0.4-0.8] pg/ml, p=0.001), IL-8 (2.1 [1.1-4.2] pg/ml vs. 0.7 [0.4-0.9] pg/ml, p<0.0001), and IL-18 (249.3 [188.5-318.7] pg/ml vs. 186.7 [139.9-243.9] pg/ml, p=0.005) as well as lower IL-10 levels than healthy pregnant women (0.6 [0.5-1.5] pg/ml vs. 2.9 [1.8-3.2] pg/ml, p<0.0001). After adjusting for glucose, insulin, and BMI values, the differences in IL-8 and IL-18 became insignificant, whereas the differences in IL-6 and IL-10 levels remained highly significant (p<0.0001). The subjects with abnormal glucose challenge test results had higher IL-6 levels (0.9 [0.7-1.3] pg/ml, p=0.005) and similar levels of other cytokines as compared with the women with normal glucose tolerance. Our results suggest an impaired balance between circulating pro- and anti-inflammatory cytokines in patients with gestational diabetes; however, a significant contribution of maternal obesity to the increased levels of IL-8 and IL-18 should be underlined. JF - Hormone and metabolic research. Hormon- und Stoffwechselforschung. Hormones et metabolisme SN - 0018-5043 AD - 1Department of Pathophysiology of Pregnancy, Medical University of Bialystok, Poland. TI - Circulating Pro- and Anti-inflammatory Cytokines in Polish Women with Gestational Diabetes. KW - il-18 KW - il-6 KW - inflammation AU - Kuzmicki, M AU - Telejko, B AU - Zonenberg, A AU - Szamatowicz, J AU - Kretowski, A AU - Nikolajuk, A AU - Laudanski, P AU - Gorska, M PY - 2008/04/30/ UR - http://dx.doi.org/10.1055/s-2008-1073166 ER -