TNF-[alpha] is an independent serum marker for proliferative retinopathy in type 1 diabetic patients

@article{citeulike:3174362, abstract = {Purpose This study aimed to determine if there are any associations between serum levels of inflammatory markers and proliferative retinopathy (PDR) in type 1 diabetic patients.Design A cross-sectional design was utilized for this study.Methods One hundred twenty-eight type 1 diabetic patients underwent stereo fundus photography according to the Early Treatment Diabetic Retinopathy Study and were divided into two retinopathy groups: no or nonproliferative retinopathy (NDR/NPDR; n=62) and PDR (n=66). Serum levels of tumor necrosis factor-[alpha] (TNF-[alpha]), interleukin (IL)-1[beta], IL-6, soluble vascular cellular adhesion molecule-1 (sVCAM-1), soluble intercellular adhesion molecule-1 (sICAM-1), P-selectin, and high-sensitivity C-reactive protein (hsCRP) were analyzed. Statistical analysis was performed using nonparametric Mann-Whitney U test and multivariate logistic regression analysis.Results Patients with PDR had higher levels of TNF-[alpha] [7.0 pg/ml (<4-17) vs. 6.0 pg/ml (<4-25); P=.009], sVCAM-1 [860 ng/ml (360-2120) vs. 700 ng/ml (310-1820); P<.001], and P-selectin [180 ng/ml (39-400) vs. 150 ng/ml (42-440); P=.017; figures are expressed as median (range)]. There were no differences in serum levels of sICAM-1 or hsCRP. IL-1[beta] was not detectable in any patient, and IL-6 was detectable in only 22.7\% of the patients. In multivariate logistic regression analysis, TNF-[alpha] was the single, persistent, independent determinant inflammatory marker for PDR.Conclusion The association between TNF-[alpha] and PDR in type 1 diabetic patients suggests that inflammation might play a role in the pathogenesis of proliferative diabetic retinopathy.}, author = {Gustavsson, Carin and Agardh, Elisabet and Bengtsson, Boel and Agardh, Carl-David}, citeulike-article-id = {3174362}, doi = {10.1016/j.jdiacomp.2007.03.001}, journal = {Journal of Diabetes and its Complications}, keywords = {diabetic-complications, tnf}, month = {}, number = {5}, pages = {309--316}, posted-at = {2008-08-30 01:17:46}, priority = {2}, title = {TNF-[alpha] is an independent serum marker for proliferative retinopathy in type 1 diabetic patients}, url = {http://dx.doi.org/10.1016/j.jdiacomp.2007.03.001}, volume = {22}, year = {2008} }

TY - JOUR ID - citeulike:3174362 L3 - citeulike-article-id:3174362 N2 - Purpose This study aimed to determine if there are any associations between serum levels of inflammatory markers and proliferative retinopathy (PDR) in type 1 diabetic patients.Design A cross-sectional design was utilized for this study.Methods One hundred twenty-eight type 1 diabetic patients underwent stereo fundus photography according to the Early Treatment Diabetic Retinopathy Study and were divided into two retinopathy groups: no or nonproliferative retinopathy (NDR/NPDR; n=62) and PDR (n=66). Serum levels of tumor necrosis factor-[alpha] (TNF-[alpha]), interleukin (IL)-1[beta], IL-6, soluble vascular cellular adhesion molecule-1 (sVCAM-1), soluble intercellular adhesion molecule-1 (sICAM-1), P-selectin, and high-sensitivity C-reactive protein (hsCRP) were analyzed. Statistical analysis was performed using nonparametric Mann-Whitney U test and multivariate logistic regression analysis.Results Patients with PDR had higher levels of TNF-[alpha] [7.0 pg/ml (<4-17) vs. 6.0 pg/ml (<4-25); P=.009], sVCAM-1 [860 ng/ml (360-2120) vs. 700 ng/ml (310-1820); P<.001], and P-selectin [180 ng/ml (39-400) vs. 150 ng/ml (42-440); P=.017; figures are expressed as median (range)]. There were no differences in serum levels of sICAM-1 or hsCRP. IL-1[beta] was not detectable in any patient, and IL-6 was detectable in only 22.7% of the patients. In multivariate logistic regression analysis, TNF-[alpha] was the single, persistent, independent determinant inflammatory marker for PDR.Conclusion The association between TNF-[alpha] and PDR in type 1 diabetic patients suggests that inflammation might play a role in the pathogenesis of proliferative diabetic retinopathy. IS - 5 JF - Journal of Diabetes and its Complications EP - 316 TI - TNF-[alpha] is an independent serum marker for proliferative retinopathy in type 1 diabetic patients VL - 22 SP - 309 KW - diabetic-complications KW - tnf AU - Gustavsson, Carin AU - Agardh, Elisabet AU - Bengtsson, Boel AU - Agardh, Carl-David PY - 2008/0// UR - http://dx.doi.org/10.1016/j.jdiacomp.2007.03.001 ER -