IkappaB kinases: key regulators of the NF-kappaB pathway. Export

@article{citeulike:3398797, abstract = {The nuclear factor (NF)-kappaB pathway is important for the expression of a wide variety of genes that are involved in the control of the host immune and inflammatory response, and in the regulation of cellular proliferation and survival. The constitutive activation of this pathway is associated with inflammatory and autoimmune diseases, such as asthma, rheumatoid arthritis and inflammatory bowel disease, in addition to atherosclerosis, Alzheimer's disease, cancer and diabetes. One of the key steps in activating the NF-kappaB pathway is the stimulation of the IkappaB (inhibitor of kappaB) kinases. Recent data indicate that these kinases activate the NF-kappaB pathway through distinct steps that are operative in both the cytoplasm and the nucleus. A better understanding of the mechanisms that activate this pathway provides the potential for defining new therapeutic targets that might prevent the aberrant activation of NF-kappaB in a variety of human diseases.}, author = {Yamamoto, Y. and Gaynor, R. B.}, citeulike-article-id = {3398797}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.tibs.2003.12.003}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/15102433}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=15102433}, doi = {10.1016/j.tibs.2003.12.003}, issn = {0968-0004}, journal = {Trends in biochemical sciences}, keywords = {nf-kb, review}, month = {February}, number = {2}, pages = {72--79}, posted-at = {2008-10-13 00:09:25}, priority = {2}, title = {IkappaB kinases: key regulators of the NF-kappaB pathway.}, url = {http://dx.doi.org/10.1016/j.tibs.2003.12.003}, volume = {29}, year = {2004} }

TY - JOUR ID - citeulike:3398797 L3 - citeulike-article-id:3398797 N2 - The nuclear factor (NF)-kappaB pathway is important for the expression of a wide variety of genes that are involved in the control of the host immune and inflammatory response, and in the regulation of cellular proliferation and survival. The constitutive activation of this pathway is associated with inflammatory and autoimmune diseases, such as asthma, rheumatoid arthritis and inflammatory bowel disease, in addition to atherosclerosis, Alzheimer's disease, cancer and diabetes. One of the key steps in activating the NF-kappaB pathway is the stimulation of the IkappaB (inhibitor of kappaB) kinases. Recent data indicate that these kinases activate the NF-kappaB pathway through distinct steps that are operative in both the cytoplasm and the nucleus. A better understanding of the mechanisms that activate this pathway provides the potential for defining new therapeutic targets that might prevent the aberrant activation of NF-kappaB in a variety of human diseases. IS - 2 JF - Trends in biochemical sciences SN - 0968-0004 EP - 79 TI - IkappaB kinases: key regulators of the NF-kappaB pathway. VL - 29 SP - 72 KW - nf-kb KW - review AU - Yamamoto, Y AU - Gaynor, RB PY - 2004/02// UR - http://dx.doi.org/10.1016/j.tibs.2003.12.003 ER -