Association between Interleukin-15 and Obesity: Interleukin-15 as a Potential Regulator of Fat Mass. Export

@article{citeulike:3662380, abstract = {Objective: IL-15 decreases lipid deposition in preadipocytes and decreases the mass of white adipose tissue in rats, indicating that IL-15 may take part in regulating this tissue. IL-15 is expressed in human skeletal muscle and skeletal muscle may be a source of plasma IL-15 and in this way regulate adipose tissue mass. Design: The relation between skeletal muscle IL-15 mRNA expression, plasma IL-15, and adipose tissue mass was studied in 199 humans divided into four groups on the basis of obesity and type 2 diabetes. Furthermore, using a DNA electrotransfer model, we assessed the effect of IL-15 overexpression in skeletal muscle of mice. Results: In humans, multiple regression analysis showed a negative association between plasma IL-15 and total fat mass (P < 0.05), trunk fat mass (P < 0.01), and percent fat mass (P < 0.05), independent of type 2 diabetes. Negative associations were also found between muscle IL-15 mRNA and obesity parameters. IL-15 overexpression in skeletal muscle of mice reduced trunk fat mass but not sc fat mass. Conclusions: Our results indicate that IL-15 may be a regulator of trunk fat mass.}, author = {Nielsen, A. R. and Hojman, P. and Erikstrup, C. and Fischer, C. P. and Plomgaard, P. and Mounier, R. and Mortensen, O. H. and Broholm, C. and Taudorf, S. and Krogh-Madsen, R. and Lindegaard, B. and Petersen, A. M. and Gehl, J. and Pedersen, B. K.}, citeulike-article-id = {3662380}, citeulike-linkout-0 = {http://dx.doi.org/10.1210/jc.2007-2561}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18697873}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18697873}, doi = {10.1210/jc.2007-2561}, issn = {0021-972X}, journal = {The Journal of clinical endocrinology and metabolism}, keywords = {il-15}, month = {November}, number = {11}, pages = {4486--4493}, posted-at = {2008-11-22 22:54:19}, priority = {2}, title = {Association between Interleukin-15 and Obesity: Interleukin-15 as a Potential Regulator of Fat Mass.}, url = {http://dx.doi.org/10.1210/jc.2007-2561}, volume = {93}, year = {2008} }

TY - JOUR ID - citeulike:3662380 L3 - citeulike-article-id:3662380 N2 - Objective: IL-15 decreases lipid deposition in preadipocytes and decreases the mass of white adipose tissue in rats, indicating that IL-15 may take part in regulating this tissue. IL-15 is expressed in human skeletal muscle and skeletal muscle may be a source of plasma IL-15 and in this way regulate adipose tissue mass. Design: The relation between skeletal muscle IL-15 mRNA expression, plasma IL-15, and adipose tissue mass was studied in 199 humans divided into four groups on the basis of obesity and type 2 diabetes. Furthermore, using a DNA electrotransfer model, we assessed the effect of IL-15 overexpression in skeletal muscle of mice. Results: In humans, multiple regression analysis showed a negative association between plasma IL-15 and total fat mass (P < 0.05), trunk fat mass (P < 0.01), and percent fat mass (P < 0.05), independent of type 2 diabetes. Negative associations were also found between muscle IL-15 mRNA and obesity parameters. IL-15 overexpression in skeletal muscle of mice reduced trunk fat mass but not sc fat mass. Conclusions: Our results indicate that IL-15 may be a regulator of trunk fat mass. IS - 11 JF - The Journal of clinical endocrinology and metabolism SN - 0021-972X EP - 4493 TI - Association between Interleukin-15 and Obesity: Interleukin-15 as a Potential Regulator of Fat Mass. VL - 93 SP - 4486 KW - il-15 AU - Nielsen, AR AU - Hojman, P AU - Erikstrup, C AU - Fischer, CP AU - Plomgaard, P AU - Mounier, R AU - Mortensen, OH AU - Broholm, C AU - Taudorf, S AU - Krogh-Madsen, R AU - Lindegaard, B AU - Petersen, AM AU - Gehl, J AU - Pedersen, BK PY - 2008/11// UR - http://dx.doi.org/10.1210/jc.2007-2561 ER -