Prospective study of physical fitness, adiposity, and inflammatory markers in healthy middle-aged men and women. Export

@article{citeulike:3855666, abstract = {BACKGROUND: Physical fitness may provide cardiovascular benefits in the obese. OBJECTIVE: We prospectively examined the associations between inflammatory markers and fitness, body mass index, and central adiposity. DESIGN: Healthy men and women (n = 176) were recruited from the Whitehall II epidemiologic cohort. At baseline we measured physical fitness and adiposity, and blood was drawn for the assessment of inflammatory markers [C-reactive protein (CRP) and interleukin-6 (IL-6)]. We subsequently assessed inflammatory markers and adiposity at the 3-y follow-up visit. RESULTS: Body mass index, but not physical fitness, was independently associated with IL-6 and CRP at follow-up. Weight gain was also associated with CRP at follow-up. Compared with fit-lean participants, the unfit-overweight participants had significantly higher concentrations of CRP (adjusted beta: 0.67; 95\% CI, 0.31, 1.00) and IL-6 (adjusted beta: 0.28; 95\% CI: -0.06, 0.49) at follow-up. In contrast, the fit-overweight and unfit-lean participants did not differ significantly from the fit-lean participants after adjustments for age, sex, smoking, employment grade, and baseline inflammation. CONCLUSIONS: In participants followed up for 3 y, changes in low-grade inflammation were positively associated with adiposity but not with fitness at baseline. Further attention should focus specifically on overweight-obese participants in relation to physical fitness and cardiovascular disease risk.}, author = {Hamer, Mark and Steptoe, Andrew}, citeulike-article-id = {3855666}, citeulike-linkout-0 = {http://dx.doi.org/10.3945/ajcn.2008.26779}, citeulike-linkout-1 = {http://www.ajcn.org/cgi/content/abstract/89/1/85?etoc}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19056563}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19056563}, day = {1}, doi = {10.3945/ajcn.2008.26779}, issn = {1938-3207}, journal = {The American journal of clinical nutrition}, keywords = {c-reactive-protein, il-6, inflammation}, month = {January}, number = {1}, pages = {85--89}, posted-at = {2009-01-07 03:23:09}, priority = {2}, title = {Prospective study of physical fitness, adiposity, and inflammatory markers in healthy middle-aged men and women.}, url = {http://dx.doi.org/10.3945/ajcn.2008.26779}, volume = {89}, year = {2009} }

TY - JOUR ID - citeulike:3855666 L3 - citeulike-article-id:3855666 N2 - BACKGROUND: Physical fitness may provide cardiovascular benefits in the obese. OBJECTIVE: We prospectively examined the associations between inflammatory markers and fitness, body mass index, and central adiposity. DESIGN: Healthy men and women (n = 176) were recruited from the Whitehall II epidemiologic cohort. At baseline we measured physical fitness and adiposity, and blood was drawn for the assessment of inflammatory markers [C-reactive protein (CRP) and interleukin-6 (IL-6)]. We subsequently assessed inflammatory markers and adiposity at the 3-y follow-up visit. RESULTS: Body mass index, but not physical fitness, was independently associated with IL-6 and CRP at follow-up. Weight gain was also associated with CRP at follow-up. Compared with fit-lean participants, the unfit-overweight participants had significantly higher concentrations of CRP (adjusted beta: 0.67; 95% CI, 0.31, 1.00) and IL-6 (adjusted beta: 0.28; 95% CI: -0.06, 0.49) at follow-up. In contrast, the fit-overweight and unfit-lean participants did not differ significantly from the fit-lean participants after adjustments for age, sex, smoking, employment grade, and baseline inflammation. CONCLUSIONS: In participants followed up for 3 y, changes in low-grade inflammation were positively associated with adiposity but not with fitness at baseline. Further attention should focus specifically on overweight-obese participants in relation to physical fitness and cardiovascular disease risk. IS - 1 JF - The American journal of clinical nutrition SN - 1938-3207 EP - 89 TI - Prospective study of physical fitness, adiposity, and inflammatory markers in healthy middle-aged men and women. VL - 89 SP - 85 KW - c-reactive-protein KW - il-6 KW - inflammation AU - Hamer, Mark AU - Steptoe, Andrew PY - 2009/01/01/ UR - http://dx.doi.org/10.3945/ajcn.2008.26779 ER -