A20 and A20-binding proteins as cellular inhibitors of nuclear factor-κB-dependent gene expression and apoptosis Export

@article{citeulike:4292855, abstract = {Proper gene expression and cell growth are critical for the survival of all organisms. Nuclear factor-kappaB (NF-κB)-dependent gene expression and apoptosis play crucial roles in numerous cellular processes, and defects in their regulation may contribute to a variety of diseases including inflammation and cancer. Although there has recently been tremendous progress in our understanding of the signaling pathways that lead to NF-κB activation and apoptosis, signaling mechanisms that negatively regulate these processes are only partially understood. This review deals with the zinc finger protein A20, which has been characterized as a dual inhibitor of NF-κB activation and apoptosis. Its inducible expression by a wide variety of stimuli, including cytokines such as tumor necrosis factor, interleukin-1, and CD40, as well as bacterial and viral products such as lipopolysaccharide, Epstein–Barr virus latent membrane protein 1, and human T-cell leukemia virus type I Tax, suggests that it is involved in the negative feedback regulation of signaling. We will discuss the possible underlying mechanisms, placing emphasis on the role of several A20-binding proteins that have recently been described. Moreover, evidence is presented that A20 and A20-binding proteins are potential novel therapeutic tools in the treatment of a variety of diseases.}, author = {Beyaert, R.}, citeulike-article-id = {4292855}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/S0006-2952(00)00404-4}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0006-2952(00)00404-4}, day = {15}, doi = {10.1016/S0006-2952(00)00404-4}, issn = {00062952}, journal = {Biochemical Pharmacology}, keywords = {a20, nf-kb, review}, month = {October}, number = {8}, pages = {1143--1151}, posted-at = {2009-04-09 02:48:22}, priority = {2}, title = {A20 and A20-binding proteins as cellular inhibitors of nuclear factor-κB-dependent gene expression and apoptosis}, url = {http://dx.doi.org/10.1016/S0006-2952(00)00404-4}, volume = {60}, year = {2000} }

TY - JOUR ID - citeulike:4292855 L3 - citeulike-article-id:4292855 N2 - Proper gene expression and cell growth are critical for the survival of all organisms. Nuclear factor-kappaB (NF-κB)-dependent gene expression and apoptosis play crucial roles in numerous cellular processes, and defects in their regulation may contribute to a variety of diseases including inflammation and cancer. Although there has recently been tremendous progress in our understanding of the signaling pathways that lead to NF-κB activation and apoptosis, signaling mechanisms that negatively regulate these processes are only partially understood. This review deals with the zinc finger protein A20, which has been characterized as a dual inhibitor of NF-κB activation and apoptosis. Its inducible expression by a wide variety of stimuli, including cytokines such as tumor necrosis factor, interleukin-1, and CD40, as well as bacterial and viral products such as lipopolysaccharide, Epstein–Barr virus latent membrane protein 1, and human T-cell leukemia virus type I Tax, suggests that it is involved in the negative feedback regulation of signaling. We will discuss the possible underlying mechanisms, placing emphasis on the role of several A20-binding proteins that have recently been described. Moreover, evidence is presented that A20 and A20-binding proteins are potential novel therapeutic tools in the treatment of a variety of diseases. IS - 8 JF - Biochemical Pharmacology SN - 00062952 EP - 1151 TI - A20 and A20-binding proteins as cellular inhibitors of nuclear factor-κB-dependent gene expression and apoptosis VL - 60 SP - 1143 KW - a20 KW - nf-kb KW - review AU - Beyaert, R PY - 2000/10/15/ UR - http://dx.doi.org/10.1016/S0006-2952(00)00404-4 ER -