The metabolic role of IL-6 produced during exercise: is IL-6 an exercise factor? Export

@article{citeulike:4381149, abstract = {For most of the last century, researchers have searched for a muscle contraction-induced factor that mediates some of the exercise effects in other tissues such as the liver and the adipose tissue. It has been called the 'work stimulus', the 'work factor' or the 'exercise factor'. In the search for such a factor, a cytokine, IL-6, was found to be produced by contracting muscles and released into the blood. It has been demonstrated that IL-6 has many biological roles such as: (1) induction of lipolysis; (2) suppression of TNF production; (3) stimulation of cortisol production. The IL-6 gene is rapidly activated during exercise, and the activation of this gene is further enhanced when muscle glycogen content is low. In addition, carbohydrate supplementation during exercise has been shown to inhibit the release of IL-6 from contracting muscle. Thus, it is suggested that muscle-derived IL-6 fulfils the criteria of an exercise factor and that such classes of cytokines could be termed 'myokines'.}, author = {Pedersen, B. K. and Steensberg, A. and Fischer, C. and Keller, C. and Keller, P. and Plomgaard, P. and Wolsk-Petersen, E. and Febbraio, M.}, citeulike-article-id = {4381149}, citeulike-linkout-0 = {http://dx.doi.org/10.1079/PNS2004338}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/15294041}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=15294041}, doi = {10.1079/PNS2004338}, issn = {0029-6651}, journal = {The Proceedings of the Nutrition Society}, keywords = {il-6}, month = {May}, number = {2}, pages = {263--267}, posted-at = {2009-04-23 00:38:47}, priority = {2}, title = {The metabolic role of IL-6 produced during exercise: is IL-6 an exercise factor?}, url = {http://dx.doi.org/10.1079/PNS2004338}, volume = {63}, year = {2004} }

TY - JOUR ID - citeulike:4381149 L3 - citeulike-article-id:4381149 N2 - For most of the last century, researchers have searched for a muscle contraction-induced factor that mediates some of the exercise effects in other tissues such as the liver and the adipose tissue. It has been called the 'work stimulus', the 'work factor' or the 'exercise factor'. In the search for such a factor, a cytokine, IL-6, was found to be produced by contracting muscles and released into the blood. It has been demonstrated that IL-6 has many biological roles such as: (1) induction of lipolysis; (2) suppression of TNF production; (3) stimulation of cortisol production. The IL-6 gene is rapidly activated during exercise, and the activation of this gene is further enhanced when muscle glycogen content is low. In addition, carbohydrate supplementation during exercise has been shown to inhibit the release of IL-6 from contracting muscle. Thus, it is suggested that muscle-derived IL-6 fulfils the criteria of an exercise factor and that such classes of cytokines could be termed 'myokines'. IS - 2 JF - The Proceedings of the Nutrition Society SN - 0029-6651 EP - 267 TI - The metabolic role of IL-6 produced during exercise: is IL-6 an exercise factor? VL - 63 SP - 263 KW - il-6 AU - Pedersen, BK AU - Steensberg, A AU - Fischer, C AU - Keller, C AU - Keller, P AU - Plomgaard, P AU - Wolsk-Petersen, E AU - Febbraio, M PY - 2004/05// UR - http://dx.doi.org/10.1079/PNS2004338 ER -