Phobic Anxiety Is Associated With Higher Serum Concentrations of Adipokines and Cytokines in Women With Diabetes Export

@article{citeulike:4446549, abstract = {OBJECTIVEPhobic anxiety has been associated with increased risk of cardiovascular disease (CVD), but the underlying mechanisms are poorly understood. We aimed to determine whether associations of phobic anxiety with several known markers of CVD might be contributors. RESEARCH DESIGN AND METHODSWe used a 16-point validated index (Crown-Crisp) measured in 1988 to categorize 984 women with type 2 diabetes from the Nurses' Health Study as having low, moderate, or high phobic anxiety. Groups were then compared for differences in adipokines (adiponectin and leptin), inflammatory markers (C-reactive protein and tumor necrosis factor [TNF]-{alpha} receptor II), and markers of endothelial function (sE-selectin, soluble intercellular adhesion molecule [sICAM]-1) measured on blood samples provided between 1989 and 1990. RESULTSHigher levels of phobic anxiety were associated with higher BMI and lower education. Higher levels of phobic anxiety were also associated with higher leptin and soluble TNF-{alpha} receptor II in both crude analyses and after adjustment for potential confounders. sICAM and sE-selectin were higher in the highest tertile compared with the middle tertile, but there was no significant trend across tertiles. We found no association between phobic anxiety and adiponectin. CONCLUSIONSHigh levels of phobic anxiety are associated with increased levels of leptin and inflammatory markers, which may in part explain the previously observed relationship between anxiety and other psychosocial disorders with CVD. 10.2337/dc08-1979}, author = {Brennan, Aoife M. and Fargnoli, Jessica L. and Williams, Catherine J. and Li, Tricia and Willett, Walter and Kawachi, I. and Qi, Lu and Hu, Frank B. and Mantzoros, Christos S.}, citeulike-article-id = {4446549}, citeulike-linkout-0 = {http://dx.doi.org/10.2337/dc08-1979}, citeulike-linkout-1 = {http://care.diabetesjournals.org/cgi/content/abstract/32/5/926}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19223611}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19223611}, day = {1}, doi = {10.2337/dc08-1979}, journal = {Diabetes Care}, keywords = {inflammation}, month = {May}, number = {5}, pages = {926--931}, posted-at = {2009-05-01 00:35:09}, priority = {2}, title = {Phobic Anxiety Is Associated With Higher Serum Concentrations of Adipokines and Cytokines in Women With Diabetes}, url = {http://dx.doi.org/10.2337/dc08-1979}, volume = {32}, year = {2009} }

TY - JOUR ID - citeulike:4446549 L3 - citeulike-article-id:4446549 N2 - OBJECTIVEPhobic anxiety has been associated with increased risk of cardiovascular disease (CVD), but the underlying mechanisms are poorly understood. We aimed to determine whether associations of phobic anxiety with several known markers of CVD might be contributors. RESEARCH DESIGN AND METHODSWe used a 16-point validated index (Crown-Crisp) measured in 1988 to categorize 984 women with type 2 diabetes from the Nurses' Health Study as having low, moderate, or high phobic anxiety. Groups were then compared for differences in adipokines (adiponectin and leptin), inflammatory markers (C-reactive protein and tumor necrosis factor [TNF]-{alpha} receptor II), and markers of endothelial function (sE-selectin, soluble intercellular adhesion molecule [sICAM]-1) measured on blood samples provided between 1989 and 1990. RESULTSHigher levels of phobic anxiety were associated with higher BMI and lower education. Higher levels of phobic anxiety were also associated with higher leptin and soluble TNF-{alpha} receptor II in both crude analyses and after adjustment for potential confounders. sICAM and sE-selectin were higher in the highest tertile compared with the middle tertile, but there was no significant trend across tertiles. We found no association between phobic anxiety and adiponectin. CONCLUSIONSHigh levels of phobic anxiety are associated with increased levels of leptin and inflammatory markers, which may in part explain the previously observed relationship between anxiety and other psychosocial disorders with CVD. 10.2337/dc08-1979 IS - 5 JF - Diabetes Care EP - 931 TI - Phobic Anxiety Is Associated With Higher Serum Concentrations of Adipokines and Cytokines in Women With Diabetes VL - 32 SP - 926 KW - inflammation AU - Brennan, Aoife AU - Fargnoli, Jessica AU - Williams, Catherine AU - Li, Tricia AU - Willett, Walter AU - Kawachi, I AU - Qi, Lu AU - Hu, Frank AU - Mantzoros, Christos PY - 2009/05/01/ UR - http://dx.doi.org/10.2337/dc08-1979 ER -