Elevated cerebrospinal fluid (CSF) leptin in idiopathic intracranial hypertension (IIH): evidence for hypothalamic leptin resistance? Export

@article{citeulike:4521852, abstract = {Objective The aetiology of idiopathic intracranial hypertension (IIH) is not known, but its association with obesity is well-recognized. Recent studies have linked obesity with abnormalities in circulating inflammatory and adiposity related cytokines. The aim of this study was to characterize adipokine and inflammatory cytokine profiles in IIH.Design  Paired serum and cerebrospinal fluid (CSF) specimens were collected from 26 patients with IIH and compared to 62 control subjects. Samples were analysed for leptin, resistin, adiponectin, insulin, IL-103B2, IL-6, IL-8 (CXCL8), TNF03B1, MCP-1 (CCL2), hepatocyte growth factor, nerve growth factor and PAI-1 using multiplex bead immunoassays.Results  CSF leptin was significantly higher in patients with IIH (P = 0·001) compared to controls after correction for age, gender and body mass index (BMI). In the control population, BMI correlated with serum leptin (r = 0·34; P = 0·007) and CSF leptin (r = 0·51; P \< 0·0001), but this was not the case for the IIH population. Profiles of other inflammatory cytokines and adipokines did not differ between IIH patients and controls once anthropometric factors had been accounted for.Conclusions  IIH was characterized by significantly elevated CSF leptin levels which did not correlate with BMI. We suggest that CSF leptin may be important in the pathophysiology of IIH and that obesity in IIH may occur as a result of hypothalamic leptin resistance.}, address = {Department of Neurology, School of Experimental Medicine, ; Academic Unit of Ophthalmology, School of Immunology, Infection and Inflammation, ; Department of Endocrinology, School of Experimental Medicine, and ; Wellcome Trust Clinical Research Facility, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK}, author = {Ball, A. K. and Sinclair, A. J. and Curnow, S. J. and Tomlinson, J. W. and Burdon, M. A. and Walker, E. A. and Stewart, P. M. and Nightingale, P. G. and Clarke, C. E. and Rauz, S.}, citeulike-article-id = {4521852}, citeulike-linkout-0 = {http://dx.doi.org/10.1111/j.1365-2265.2008.03401.x}, citeulike-linkout-1 = {http://www3.interscience.wiley.com/cgi-bin/abstract/121393633/ABSTRACT}, doi = {10.1111/j.1365-2265.2008.03401.x}, journal = {Clinical Endocrinology}, keywords = {grattan-lab-journal-club}, number = {6}, pages = {863--869}, posted-at = {2009-05-15 00:45:11}, priority = {2}, title = {Elevated cerebrospinal fluid (CSF) leptin in idiopathic intracranial hypertension (IIH): evidence for hypothalamic leptin resistance?}, url = {http://dx.doi.org/10.1111/j.1365-2265.2008.03401.x}, volume = {70}, year = {2009} }

TY - JOUR ID - citeulike:4521852 L3 - citeulike-article-id:4521852 N2 - Objective The aetiology of idiopathic intracranial hypertension (IIH) is not known, but its association with obesity is well-recognized. Recent studies have linked obesity with abnormalities in circulating inflammatory and adiposity related cytokines. The aim of this study was to characterize adipokine and inflammatory cytokine profiles in IIH.Design  Paired serum and cerebrospinal fluid (CSF) specimens were collected from 26 patients with IIH and compared to 62 control subjects. Samples were analysed for leptin, resistin, adiponectin, insulin, IL-103B2, IL-6, IL-8 (CXCL8), TNF03B1, MCP-1 (CCL2), hepatocyte growth factor, nerve growth factor and PAI-1 using multiplex bead immunoassays.Results  CSF leptin was significantly higher in patients with IIH (P = 0·001) compared to controls after correction for age, gender and body mass index (BMI). In the control population, BMI correlated with serum leptin (r = 0·34; P = 0·007) and CSF leptin (r = 0·51; P < 0·0001), but this was not the case for the IIH population. Profiles of other inflammatory cytokines and adipokines did not differ between IIH patients and controls once anthropometric factors had been accounted for.Conclusions  IIH was characterized by significantly elevated CSF leptin levels which did not correlate with BMI. We suggest that CSF leptin may be important in the pathophysiology of IIH and that obesity in IIH may occur as a result of hypothalamic leptin resistance. IS - 6 JF - Clinical Endocrinology AD - Department of Neurology, School of Experimental Medicine, ; Academic Unit of Ophthalmology, School of Immunology, Infection and Inflammation, ; Department of Endocrinology, School of Experimental Medicine, and ; Wellcome Trust Clinical Research Facility, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK EP - 869 TI - Elevated cerebrospinal fluid (CSF) leptin in idiopathic intracranial hypertension (IIH): evidence for hypothalamic leptin resistance? VL - 70 SP - 863 KW - grattan-lab-journal-club AU - Ball, AK AU - Sinclair, AJ AU - Curnow, SJ AU - Tomlinson, JW AU - Burdon, MA AU - Walker, EA AU - Stewart, PM AU - Nightingale, PG AU - Clarke, CE AU - Rauz, S PY - 2009/// UR - http://dx.doi.org/10.1111/j.1365-2265.2008.03401.x ER -