IL-18 overexpression promotes vascular inflammation and remodeling in a rat model of metabolic syndrome Export

@article{citeulike:5457777, abstract = {Although considerable evidence implicates the cytokine interlukin-18 (IL-18) in metabolic syndrome (MetS), the direct effect of IL-18 on vascular changes of MetS remains unknown. We investigated the chronic in vivo effect of IL-18 on development of MetS and vascular inflammation and remodeling by overexpressing IL-18 protein in fructose-fed rats (FFR), a model of MetS using intravenous administration of an adenovirus encoding rat IL-18. Increased serum IL-18 and vascular inflammatory response were found in FFR. Overexpreesion of IL-18 aggravated insulin resistance and enhance vascular inflammation and remodeling, which can be reflected by increased aortic expressions of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) and enhanced infiltration of macrophages and increased aortic wall thickness and wall-to-lumen ratio. Interestingly, the levels of interleukin-1 receptor-associated kinase 1 (IRAK1) and the activity of nucleus factor-κB (NF-κB) were also significantly increased. Together, these results indicated that chronic elevated IL-18 levels at a supraphsiological concentration aggravated insulin resistance, enhanced vascular inflammation and remodeling, probably by increasing the level of IRAK1 and the activity of NF-κB. Targeting expression of IL-18 or its specific downstream mediators may retard the progression of MetS and its complications.}, author = {Tan, Hong-wei and Liu, Xu and Bi, Xiu-ping and Xing, Shan-shan and Li, Li and Gong, Hui-ping and Zhong, Ming and Wang, Zhi-hao and Zhang, Yun and Zhang, Wei}, citeulike-article-id = {5457777}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.atherosclerosis.2009.07.053}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0021915009006200}, day = {07}, doi = {10.1016/j.atherosclerosis.2009.07.053}, issn = {00219150}, journal = {Atherosclerosis}, keywords = {cardiovascular-disease, il-18, il18-review}, month = {August}, posted-at = {2009-09-07 00:24:18}, priority = {2}, title = {IL-18 overexpression promotes vascular inflammation and remodeling in a rat model of metabolic syndrome}, url = {http://dx.doi.org/10.1016/j.atherosclerosis.2009.07.053}, year = {2009} }

TY - JOUR ID - citeulike:5457777 L3 - citeulike-article-id:5457777 N2 - Although considerable evidence implicates the cytokine interlukin-18 (IL-18) in metabolic syndrome (MetS), the direct effect of IL-18 on vascular changes of MetS remains unknown. We investigated the chronic in vivo effect of IL-18 on development of MetS and vascular inflammation and remodeling by overexpressing IL-18 protein in fructose-fed rats (FFR), a model of MetS using intravenous administration of an adenovirus encoding rat IL-18. Increased serum IL-18 and vascular inflammatory response were found in FFR. Overexpreesion of IL-18 aggravated insulin resistance and enhance vascular inflammation and remodeling, which can be reflected by increased aortic expressions of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) and enhanced infiltration of macrophages and increased aortic wall thickness and wall-to-lumen ratio. Interestingly, the levels of interleukin-1 receptor-associated kinase 1 (IRAK1) and the activity of nucleus factor-κB (NF-κB) were also significantly increased. Together, these results indicated that chronic elevated IL-18 levels at a supraphsiological concentration aggravated insulin resistance, enhanced vascular inflammation and remodeling, probably by increasing the level of IRAK1 and the activity of NF-κB. Targeting expression of IL-18 or its specific downstream mediators may retard the progression of MetS and its complications. JF - Atherosclerosis SN - 00219150 TI - IL-18 overexpression promotes vascular inflammation and remodeling in a rat model of metabolic syndrome KW - cardiovascular-disease KW - il-18 KW - il18-review AU - Tan, Hong-wei AU - Liu, Xu AU - Bi, Xiu-ping AU - Xing, Shan-shan AU - Li, Li AU - Gong, Hui-ping AU - Zhong, Ming AU - Wang, Zhi-hao AU - Zhang, Yun AU - Zhang, Wei PY - 2009/08/07/ UR - http://dx.doi.org/10.1016/j.atherosclerosis.2009.07.053 ER -