Association of interleukin-18 promoter polymorphism and atherosclerotic diseases in Chinese patients with diabetic nephropathy Export

@article{citeulike:5686334, abstract = {Aim:  Interleukin-18 (IL-18) is a pro-inflammatory cytokine and possibly plays an important role in the pathogenesis of cardiovascular disease. The relationship between two IL-18 gene polymorphisms, namely C-607A and G-137C, and cardiovascular disease in patients with diabetic nephropathy was examined.Methods:   Two hundred and twenty patients (91 male) with diabetic nephropathy were studied. The IL-18 promoter genotypes were determined. All patients were then prospectively followed for the cardiovascular events. Cardiovascular mortality and all-cause mortality were also compared.Results:   Mean age was 64.3 ± 10.6 years; average follow up was 73.9 ± 33.6 months. The frequencies of CC, CA and AA genotypes of the C-607A polymorphism were 25.5\%, 48.2\% and 26.8\%, respectively; GG, GC and CC genotypes of the G-137C polymorphism were 71.8\%, 25.0\% and 3.2\%, respectively. Neither of the polymorphisms were associated with the development of primary cardiovascular end-point. Cardiovascular survival was 84.8\% and 70.6\% at 60 months for GG and GC/CC genotypes of the G-137C polymorphism, respectively (P = 0.027); the corresponding actuarial survival was 69.0\% and 54.8\%, respectively (P = 0.053). However, the G-137C genotype was not an independent predictor of cardiovascular or actuarial survival after adjusting for confounders by multivariate analysis with the Cox model. The C-607A polymorphism had no significant effect on cardiovascular or actuarial survival.Conclusion:   The G-137C polymorphism of the IL-18 promoter is associated with the cardiovascular mortality, and a trend of association with all-cause mortality, in patients with diabetic nephropathy. The association, however, becomes insignificant after adjusting for confounding factors. Further studies are needed to test other genetic determinants of the association between systemic inflammation and cardiovascular disease in renal failure patients.}, address = {Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong, China}, author = {Cheuk-Chun Szet, O. and Kai-Ming Cho, W. and Peter yam-Kau Poo, N. and Bonnie ching-Ha Kwa, N. and Philip kam-Tao, L. I.}, citeulike-article-id = {5686334}, citeulike-linkout-0 = {http://dx.doi.org/10.1111/j.1440-1797.2008.01075.x}, citeulike-linkout-1 = {http://www3.interscience.wiley.com/cgi-bin/abstract/122577962/ABSTRACT}, doi = {10.1111/j.1440-1797.2008.01075.x}, issn = {1440-1797}, journal = {Nephrology}, keywords = {cardiovascular-disease, il-18, il18-review}, number = {6}, pages = {606--612}, posted-at = {2009-08-31 01:13:08}, priority = {2}, title = {Association of interleukin-18 promoter polymorphism and atherosclerotic diseases in Chinese patients with diabetic nephropathy}, url = {http://dx.doi.org/10.1111/j.1440-1797.2008.01075.x}, volume = {14}, year = {2009} }

TY - JOUR ID - citeulike:5686334 L3 - citeulike-article-id:5686334 N2 - Aim:  Interleukin-18 (IL-18) is a pro-inflammatory cytokine and possibly plays an important role in the pathogenesis of cardiovascular disease. The relationship between two IL-18 gene polymorphisms, namely C-607A and G-137C, and cardiovascular disease in patients with diabetic nephropathy was examined.Methods:   Two hundred and twenty patients (91 male) with diabetic nephropathy were studied. The IL-18 promoter genotypes were determined. All patients were then prospectively followed for the cardiovascular events. Cardiovascular mortality and all-cause mortality were also compared.Results:   Mean age was 64.3 ± 10.6 years; average follow up was 73.9 ± 33.6 months. The frequencies of CC, CA and AA genotypes of the C-607A polymorphism were 25.5%, 48.2% and 26.8%, respectively; GG, GC and CC genotypes of the G-137C polymorphism were 71.8%, 25.0% and 3.2%, respectively. Neither of the polymorphisms were associated with the development of primary cardiovascular end-point. Cardiovascular survival was 84.8% and 70.6% at 60 months for GG and GC/CC genotypes of the G-137C polymorphism, respectively (P = 0.027); the corresponding actuarial survival was 69.0% and 54.8%, respectively (P = 0.053). However, the G-137C genotype was not an independent predictor of cardiovascular or actuarial survival after adjusting for confounders by multivariate analysis with the Cox model. The C-607A polymorphism had no significant effect on cardiovascular or actuarial survival.Conclusion:   The G-137C polymorphism of the IL-18 promoter is associated with the cardiovascular mortality, and a trend of association with all-cause mortality, in patients with diabetic nephropathy. The association, however, becomes insignificant after adjusting for confounding factors. Further studies are needed to test other genetic determinants of the association between systemic inflammation and cardiovascular disease in renal failure patients. IS - 6 JF - Nephrology SN - 1440-1797 AD - Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong, China EP - 612 TI - Association of interleukin-18 promoter polymorphism and atherosclerotic diseases in Chinese patients with diabetic nephropathy VL - 14 SP - 606 KW - cardiovascular-disease KW - il-18 KW - il18-review AU - Cheuk-Chun Szet, O AU - Kai-Ming Cho, W AU - Peter yam-Kau Poo, N AU - Bonnie ching-Ha Kwa, N AU - Philip kam-Tao, LI PY - 2009/// UR - http://dx.doi.org/10.1111/j.1440-1797.2008.01075.x ER -