Correlation of the leptin:adiponectin ratio with measures of insulin resistance in non-diabetic individuals Export

@article{citeulike:5811943, abstract = {Abstract Aims/hypothesis\ \ Obesity is the dominant cause of insulin resistance. In adult humans it is characterised by a combination of adipocyte hypertrophy and, to a lesser extent, adipocyte hyperplasia. As hypertrophic adipocytes secrete more leptin and less adiponectin, the plasma leptin:adiponectin ratio (LAR) has been proposed as a potentially useful measure of insulin resistance and vascular risk. We sought to assess the usefulness of the LAR as a measure of insulin resistance in non-diabetic white adults. Methods\ \ Leptin and adiponectin levels were measured in 2,097 non-diabetic individuals from the Ely and European Group for the Study of Insulin Resistance (EGIR) Relationship between Insulin Sensitivity and Cardiovascular Risk (RISC) study cohorts. LAR was compared with fasting insulin and HOMA-derived insulin sensitivity (HOMA-S) in all individuals and with the insulin sensitivity index (M/I) from hyperinsulinaemic–euglycaemic clamp studies in 1,226 EGIR RISC participants. Results\ \ The LAR was highly correlated with HOMA-S in men (r = −0.58, p = 4.5 × 10−33 and r = −0.65, p = 1.1 × 10−66 within the Ely and EGIR RISC study cohorts, respectively) and in women (r = −0.51, p = 2.8 × 10−36 and r = −0.61, p = 2.5 × 10−73). The LAR was also strongly correlated with the clamp M/I value (r = −0.52, p = 4.5 × 10−38 and r = −0.47, p = 6.6 × 10−40 in men and women, respectively), similar to correlations between HOMA-S and the M/I value. Conclusions/interpretation\ \ The leptin:adiponectin ratio is a useful measure of insulin resistance in non-diabetic white adults. These data highlight the central role of adipocyte dysfunction in the pathogenesis of insulin resistance. Given that variations between fasting and postprandial leptin and adiponectin levels tend to be small, the leptin to adiponectin ratio might also have potential value in assessing insulin sensitivity in the non-fasted state.}, author = {Finucane, F. and Luan, J. and Wareham, N. and Sharp, S. and O'Rahilly, S. and Balkau, B. and Flyvbjerg, A. and Walker, M. and H{\o}jlund, K. and Nolan, J. and on behalf of the European Group for the Study of Insulin Resistance and Savage, D.}, citeulike-article-id = {5811943}, citeulike-linkout-0 = {http://dx.doi.org/10.1007/s00125-009-1508-3}, citeulike-linkout-1 = {http://www.springerlink.com/content/j318257813633q2v}, day = {1}, doi = {10.1007/s00125-009-1508-3}, journal = {Diabetologia}, keywords = {adiponectin, adipose-tissue, insulin-resistance, leptin}, month = {November}, number = {11}, pages = {2345--2349}, posted-at = {2009-10-12 00:23:34}, priority = {2}, title = {Correlation of the leptin:adiponectin ratio with measures of insulin resistance in non-diabetic individuals}, url = {http://dx.doi.org/10.1007/s00125-009-1508-3}, volume = {52}, year = {2009} }

TY - JOUR ID - citeulike:5811943 L3 - citeulike-article-id:5811943 N2 - Abstract Aims/hypothesis  Obesity is the dominant cause of insulin resistance. In adult humans it is characterised by a combination of adipocyte hypertrophy and, to a lesser extent, adipocyte hyperplasia. As hypertrophic adipocytes secrete more leptin and less adiponectin, the plasma leptin:adiponectin ratio (LAR) has been proposed as a potentially useful measure of insulin resistance and vascular risk. We sought to assess the usefulness of the LAR as a measure of insulin resistance in non-diabetic white adults. Methods  Leptin and adiponectin levels were measured in 2,097 non-diabetic individuals from the Ely and European Group for the Study of Insulin Resistance (EGIR) Relationship between Insulin Sensitivity and Cardiovascular Risk (RISC) study cohorts. LAR was compared with fasting insulin and HOMA-derived insulin sensitivity (HOMA-S) in all individuals and with the insulin sensitivity index (M/I) from hyperinsulinaemic–euglycaemic clamp studies in 1,226 EGIR RISC participants. Results  The LAR was highly correlated with HOMA-S in men (r = −0.58, p = 4.5 × 10−33 and r = −0.65, p = 1.1 × 10−66 within the Ely and EGIR RISC study cohorts, respectively) and in women (r = −0.51, p = 2.8 × 10−36 and r = −0.61, p = 2.5 × 10−73). The LAR was also strongly correlated with the clamp M/I value (r = −0.52, p = 4.5 × 10−38 and r = −0.47, p = 6.6 × 10−40 in men and women, respectively), similar to correlations between HOMA-S and the M/I value. Conclusions/interpretation  The leptin:adiponectin ratio is a useful measure of insulin resistance in non-diabetic white adults. These data highlight the central role of adipocyte dysfunction in the pathogenesis of insulin resistance. Given that variations between fasting and postprandial leptin and adiponectin levels tend to be small, the leptin to adiponectin ratio might also have potential value in assessing insulin sensitivity in the non-fasted state. IS - 11 JF - Diabetologia EP - 2349 TI - Correlation of the leptin:adiponectin ratio with measures of insulin resistance in non-diabetic individuals VL - 52 SP - 2345 KW - adiponectin KW - adipose-tissue KW - insulin-resistance KW - leptin AU - Finucane, F AU - Luan, J AU - Wareham, N AU - Sharp, S AU - O’Rahilly, S AU - Balkau, B AU - Flyvbjerg, A AU - Walker, M AU - Højlund, K AU - Nolan, J AU - on behalf of the European Group for the Study of Insulin Resistance AU - Savage, D PY - 2009/11/01/ UR - http://dx.doi.org/10.1007/s00125-009-1508-3 ER -