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Does hypothalamic inflammation cause obesity? Export

Cell metabolism, Vol. 10, No. 4. (October 2009), pp. 241-242.

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editorial hypothalamus inflammation myd88

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Obesity-induced inflammation causes cellular resistance to both insulin and leptin. In this issue, Brüning and colleagues (Kleinridders et al., 2009) add to growing evidence that this response occurs in the hypothalamus, as well as in peripheral tissues, which helps to explain how high-fat feeding induces a gradual increase in defended body weight.


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