Predictive value of cytokine gene polymorphisms for the development of end-stage renal disease. Export

@article{citeulike:6071785, abstract = {BACKGROUND: Cytokines play a crucial role in different immunopathological conditions. Cytokine secretion is reported to be determined by polymorphisms in the cytokine genes. Since TNF-alfa and IL-10 are involved in regulation of inflammation, and TGF-beta 1 can induce fibrosis and renal insufficiency - dominant features of end-stage renal disease (ESRD), we explored the hypothesis that polymorphisms of these cytokine genes may be possible genetic susceptibility factors for the progression of renal failure. METHODS: We studied the IL-10 (-1082), TNF-alfa (-308), TGF-beta 1 (codon 10;25) gene single nucleotide polymorphisms in 118 healthy donors and 103 patients with ESRD (44 hemodialysis patients with diabetic nephropathy and 59 hemodialysis patients with glomerulonephritis) using PCR-SSP. RESULTS: Significant associations of ESRD with the TGF-beta 1 (codon 10) TT (odds ratio [OR] = 5.31; 95\% confidence interval [95\% CI], 3.77-7.02; p<0.001) and IL-10 (-1082) GG (OR=2.35; 95\% CI, 1.67-3.15; p<0.01) genotypes were found. Statistical analysis of genotype frequencies made separately for the underlying renal disease (diabetes or glomerulo-nephritis) revealed the same linkage trend: TGF-beta 1 (codon 10) TT and IL-10 (-1082) GG were associated with type 2 diabetic nephropathy (p<0.001 and p<0.05, respectively) and chronic glomerulonephritis (p<0.001 and p<0.01, respectively). No significant differences in the TNF-alfa , TGF-beta 1 (codon 25) genotype distribution between healthy controls and patients with diabetic nephropathy- or glomerulonephritis-associated ESRD were detected. CONCLUSIONS: Carriage of the TGF-beta 1 (codon 10) TT and IL-10 (-1082) GG genotypes may increase susceptibility to ESRD in German patients with type 2 diabetes or glomerulonephritis.}, author = {Babel, Nina and Gabdrakhmanova, Lelia and Hammer, Markus H. and Schoenemann, Constanze and Skrypnikov, Volodimir and Poliak, Nina and Volk, Hans-Dieter D. and Reinke, Petra}, citeulike-article-id = {6071785}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/17173255}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=17173255}, issn = {1121-8428}, journal = {Journal of nephrology}, keywords = {diabetic-complications, genetic-polymorphism, il-10}, number = {6}, pages = {802--807}, posted-at = {2009-11-04 23:46:58}, priority = {2}, title = {Predictive value of cytokine gene polymorphisms for the development of end-stage renal disease.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/17173255}, volume = {19}, year = {2006} }

TY - JOUR ID - citeulike:6071785 L3 - citeulike-article-id:6071785 N2 - BACKGROUND: Cytokines play a crucial role in different immunopathological conditions. Cytokine secretion is reported to be determined by polymorphisms in the cytokine genes. Since TNF-alfa and IL-10 are involved in regulation of inflammation, and TGF-beta 1 can induce fibrosis and renal insufficiency - dominant features of end-stage renal disease (ESRD), we explored the hypothesis that polymorphisms of these cytokine genes may be possible genetic susceptibility factors for the progression of renal failure. METHODS: We studied the IL-10 (-1082), TNF-alfa (-308), TGF-beta 1 (codon 10;25) gene single nucleotide polymorphisms in 118 healthy donors and 103 patients with ESRD (44 hemodialysis patients with diabetic nephropathy and 59 hemodialysis patients with glomerulonephritis) using PCR-SSP. RESULTS: Significant associations of ESRD with the TGF-beta 1 (codon 10) TT (odds ratio [OR] = 5.31; 95% confidence interval [95% CI], 3.77-7.02; p<0.001) and IL-10 (-1082) GG (OR=2.35; 95% CI, 1.67-3.15; p<0.01) genotypes were found. Statistical analysis of genotype frequencies made separately for the underlying renal disease (diabetes or glomerulo-nephritis) revealed the same linkage trend: TGF-beta 1 (codon 10) TT and IL-10 (-1082) GG were associated with type 2 diabetic nephropathy (p<0.001 and p<0.05, respectively) and chronic glomerulonephritis (p<0.001 and p<0.01, respectively). No significant differences in the TNF-alfa , TGF-beta 1 (codon 25) genotype distribution between healthy controls and patients with diabetic nephropathy- or glomerulonephritis-associated ESRD were detected. CONCLUSIONS: Carriage of the TGF-beta 1 (codon 10) TT and IL-10 (-1082) GG genotypes may increase susceptibility to ESRD in German patients with type 2 diabetes or glomerulonephritis. IS - 6 JF - Journal of nephrology SN - 1121-8428 EP - 807 TI - Predictive value of cytokine gene polymorphisms for the development of end-stage renal disease. VL - 19 SP - 802 KW - diabetic-complications KW - genetic-polymorphism KW - il-10 AU - Babel, Nina AU - Gabdrakhmanova, Lelia AU - Hammer, Markus AU - Schoenemann, Constanze AU - Skrypnikov, Volodimir AU - Poliak, Nina AU - Volk, Hans-Dieter AU - Reinke, Petra PY - 2006///c UR - http://view.ncbi.nlm.nih.gov/pubmed/17173255 ER -