Variants of the interleukin-10 promoter gene are associated with obesity and insulin resistance but not type 2 diabetes in caucasian italian subjects. Export

@article{citeulike:6071787, abstract = {Interleukin (IL)-10 is a major anti-inflammatory cytokine that has been associated with obesity and type 2 diabetes. The three polymorphisms -1082G/A, -819C/T, and -592C/A in the IL10 promoter were reported to influence IL10 transcription. We investigated whether these polymorphisms were associated with type 2 diabetes and related traits in a cohort of Italian Caucasians comprising 551 type 2 diabetic and 1,131 control subjects. The -819C/T and -592C/A polymorphisms were in perfect linkage disequilibrium (r(2) = 1.0). The -1082G/A polymorphism was not associated with type 2 diabetes or related traits. Although the -592C/A polymorphism was not associated with type 2 diabetes, nondiabetic homozygous carriers of the A allele showed increased BMI and insulin resistance and lower plasma IL-10 levels compared with the other genotypes. In the nondiabetic group, the ATA haplotype was associated with an increased risk for obesity (odds ratio 1.28 [95\% CI 1.02-1.60]; P = 0.02). The ATA/ATA composite genotype was associated with an increased risk for obesity (1.96 [1.16-3.31]; P = 0.01) and insulin resistance (1.99 [1.12-3.53]; P = 0.01). This study suggests that polymorphisms and haplotypes of the IL10 promoter may be associated with obesity and insulin resistance in a large sample of Italian Caucasians.}, author = {Scarpelli, Daniela and Cardellini, Marina and Andreozzi, Francesco and Laratta, Emanuela and Hribal, Marta Letizia L. and Marini, Maria Adelaide A. and Tassi, Vittorio and Lauro, Renato and Perticone, Francesco and Sesti, Giorgio}, citeulike-article-id = {6071787}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/16644716}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=16644716}, issn = {0012-1797}, journal = {Diabetes}, keywords = {genetic-polymorphism, il-10}, month = {May}, number = {5}, pages = {1529--1533}, posted-at = {2009-11-04 23:48:11}, priority = {2}, title = {Variants of the interleukin-10 promoter gene are associated with obesity and insulin resistance but not type 2 diabetes in caucasian italian subjects.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/16644716}, volume = {55}, year = {2006} }

TY - JOUR ID - citeulike:6071787 L3 - citeulike-article-id:6071787 N2 - Interleukin (IL)-10 is a major anti-inflammatory cytokine that has been associated with obesity and type 2 diabetes. The three polymorphisms -1082G/A, -819C/T, and -592C/A in the IL10 promoter were reported to influence IL10 transcription. We investigated whether these polymorphisms were associated with type 2 diabetes and related traits in a cohort of Italian Caucasians comprising 551 type 2 diabetic and 1,131 control subjects. The -819C/T and -592C/A polymorphisms were in perfect linkage disequilibrium (r(2) = 1.0). The -1082G/A polymorphism was not associated with type 2 diabetes or related traits. Although the -592C/A polymorphism was not associated with type 2 diabetes, nondiabetic homozygous carriers of the A allele showed increased BMI and insulin resistance and lower plasma IL-10 levels compared with the other genotypes. In the nondiabetic group, the ATA haplotype was associated with an increased risk for obesity (odds ratio 1.28 [95% CI 1.02-1.60]; P = 0.02). The ATA/ATA composite genotype was associated with an increased risk for obesity (1.96 [1.16-3.31]; P = 0.01) and insulin resistance (1.99 [1.12-3.53]; P = 0.01). This study suggests that polymorphisms and haplotypes of the IL10 promoter may be associated with obesity and insulin resistance in a large sample of Italian Caucasians. IS - 5 JF - Diabetes SN - 0012-1797 EP - 1533 TI - Variants of the interleukin-10 promoter gene are associated with obesity and insulin resistance but not type 2 diabetes in caucasian italian subjects. VL - 55 SP - 1529 KW - genetic-polymorphism KW - il-10 AU - Scarpelli, Daniela AU - Cardellini, Marina AU - Andreozzi, Francesco AU - Laratta, Emanuela AU - Hribal, Marta Letizia AU - Marini, Maria Adelaide AU - Tassi, Vittorio AU - Lauro, Renato AU - Perticone, Francesco AU - Sesti, Giorgio PY - 2006/05// UR - http://view.ncbi.nlm.nih.gov/pubmed/16644716 ER -