Adipocytokines and the metabolic syndrome among older persons with and without obesity - the InCHIANTI Study. Export

@article{citeulike:6071895, abstract = {SUMMARY Objective: Adipose tissue-derived inflammation may contribute to metabolic alterations and eventually to the metabolic syndrome (MetS). The purpose of this study was to: 1) examine the role of adipocytokines in the association between obesity and the MetS; and 2) to determine whether the association is different in obese and non-obese persons. Design: Cross-sectional population-based InCHIANTI study. Subjects: 944 community-dwelling adults aged 65 years and older living in Tuscany, Italy. Measurements: Obesity was defined as body mass index >/= 30 kg/m(2) and MetS as >/= 3 of the ATP-III criteria. Circulating levels of CRP, IL-6, IL-1ra, IL-18, TNF-alpha R1, adiponectin, resistin, and leptin were measured. Additionally, insulin resistance was determined using the homeostasis model assessment (HOMA-IR). Results: The prevalence of the MetS was 32\%. Both overall and abdominal obesity were significantly associated with the MetS after adjusting for inflammatory cytokines, adipokines and lifestyle factors. After adjusting for multiple confounders and HOMA-IR, IL-1ra, TNF-alpha R1 and adiponectin (p < 0.05) remained significantly associated with the MetS. Having multiple cytokines in the highest tertile increased the likelihood of having the MetS in both obese (p for trend 0.002) and non-obese persons (p for trend 0.001) independent of insulin resistance. Conclusions: Non-obese and obese individuals who develop an intense pro-inflammatory state may be more prone to develop the MetS than those with lower levels of inflammation.}, author = {Stenholm, Sari and Koster, Annemarie and Alley, Dawn E. and Visser, Marjolein and Maggio, Marcello and Harris, Tamara B. and Egan, Josephine M. and Bandinelli, Stefania and Guralnik, Jack M. and Ferrucci, Luigi}, citeulike-article-id = {6071895}, citeulike-linkout-0 = {http://dx.doi.org/10.1111/j.1365-2265.2009.03742.x}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19878507}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19878507}, day = {31}, doi = {10.1111/j.1365-2265.2009.03742.x}, issn = {1365-2265}, journal = {Clinical endocrinology}, keywords = {c-reactive-protein, il-18, metabolic-syndrome}, month = {October}, posted-at = {2009-11-05 00:40:33}, priority = {2}, title = {Adipocytokines and the metabolic syndrome among older persons with and without obesity - the InCHIANTI Study.}, url = {http://dx.doi.org/10.1111/j.1365-2265.2009.03742.x}, year = {2009} }

TY - JOUR ID - citeulike:6071895 L3 - citeulike-article-id:6071895 N2 - SUMMARY Objective: Adipose tissue-derived inflammation may contribute to metabolic alterations and eventually to the metabolic syndrome (MetS). The purpose of this study was to: 1) examine the role of adipocytokines in the association between obesity and the MetS; and 2) to determine whether the association is different in obese and non-obese persons. Design: Cross-sectional population-based InCHIANTI study. Subjects: 944 community-dwelling adults aged 65 years and older living in Tuscany, Italy. Measurements: Obesity was defined as body mass index >/= 30 kg/m(2) and MetS as >/= 3 of the ATP-III criteria. Circulating levels of CRP, IL-6, IL-1ra, IL-18, TNF-alpha R1, adiponectin, resistin, and leptin were measured. Additionally, insulin resistance was determined using the homeostasis model assessment (HOMA-IR). Results: The prevalence of the MetS was 32%. Both overall and abdominal obesity were significantly associated with the MetS after adjusting for inflammatory cytokines, adipokines and lifestyle factors. After adjusting for multiple confounders and HOMA-IR, IL-1ra, TNF-alpha R1 and adiponectin (p < 0.05) remained significantly associated with the MetS. Having multiple cytokines in the highest tertile increased the likelihood of having the MetS in both obese (p for trend 0.002) and non-obese persons (p for trend 0.001) independent of insulin resistance. Conclusions: Non-obese and obese individuals who develop an intense pro-inflammatory state may be more prone to develop the MetS than those with lower levels of inflammation. JF - Clinical endocrinology SN - 1365-2265 TI - Adipocytokines and the metabolic syndrome among older persons with and without obesity - the InCHIANTI Study. KW - c-reactive-protein KW - il-18 KW - metabolic-syndrome AU - Stenholm, Sari AU - Koster, Annemarie AU - Alley, Dawn AU - Visser, Marjolein AU - Maggio, Marcello AU - Harris, Tamara AU - Egan, Josephine AU - Bandinelli, Stefania AU - Guralnik, Jack AU - Ferrucci, Luigi PY - 2009/10/31/ UR - http://dx.doi.org/10.1111/j.1365-2265.2009.03742.x ER -