Regulation of NF-kappaB activity through lysine monomethylation of p65. Export

@article{citeulike:6095850, abstract = {NF-kappaB is a key activator of inflammatory and immune responses with important pathological roles in cancer, heart disease, and autoimmune diseases. Transcriptional activity of NF-kappaB is regulated by different posttranslational modifications. Here, we report a novel mechanism of NF-kappaB regulation through lysine monomethylation by SET9 methyltransferase. Set9 specifically methylates p65 at lysine 37. Both TNFalpha and IL-1beta treatments induced methylation of p65. Methylated p65 is restricted to the nucleus and this modification regulates the promoter binding of p65. Moreover, Set9 mediated methylation of p65 is required for the expression of a subset of NF-kappaB target genes in response to TNFalpha stimulation.}, author = {Ea, Chee-Kwee K. and Baltimore, David}, citeulike-article-id = {6095850}, citeulike-linkout-0 = {http://dx.doi.org/10.1073/pnas.0910439106}, citeulike-linkout-1 = {http://www.pnas.org/content/106/45/18972.abstract}, citeulike-linkout-2 = {http://www.pnas.org/content/106/45/18972.full.pdf}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/19864627}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=19864627}, day = {10}, doi = {10.1073/pnas.0910439106}, issn = {1091-6490}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, keywords = {il-1, nf-kb, tnf}, month = {November}, number = {45}, pages = {18972--18977}, posted-at = {2009-11-11 01:08:47}, priority = {2}, title = {Regulation of NF-kappaB activity through lysine monomethylation of p65.}, url = {http://dx.doi.org/10.1073/pnas.0910439106}, volume = {106}, year = {2009} }

TY - JOUR ID - citeulike:6095850 L3 - citeulike-article-id:6095850 N2 - NF-kappaB is a key activator of inflammatory and immune responses with important pathological roles in cancer, heart disease, and autoimmune diseases. Transcriptional activity of NF-kappaB is regulated by different posttranslational modifications. Here, we report a novel mechanism of NF-kappaB regulation through lysine monomethylation by SET9 methyltransferase. Set9 specifically methylates p65 at lysine 37. Both TNFalpha and IL-1beta treatments induced methylation of p65. Methylated p65 is restricted to the nucleus and this modification regulates the promoter binding of p65. Moreover, Set9 mediated methylation of p65 is required for the expression of a subset of NF-kappaB target genes in response to TNFalpha stimulation. IS - 45 JF - Proceedings of the National Academy of Sciences of the United States of America SN - 1091-6490 EP - 18977 TI - Regulation of NF-kappaB activity through lysine monomethylation of p65. VL - 106 SP - 18972 KW - il-1 KW - nf-kb KW - tnf AU - Ea, Chee-Kwee AU - Baltimore, David PY - 2009/11/10/ UR - http://dx.doi.org/10.1073/pnas.0910439106 ER -