An ecological and evolutionary perspective on humanâmicrobe mutualism and disease Export

@article{citeulike:1794662, abstract = {The microbial communities of humans are characteristic and complex mixtures of microorganisms that have co-evolved with their human hosts. The species that make up these communities vary between hosts as a result of restricted migration of microorganisms between hosts and strong ecological interactions within hosts, as well as host variability in terms of diet, genotype and colonization history. The shared evolutionary fate of humans and their symbiotic bacteria has selected for mutualistic interactions that are essential for human health, and ecological or genetic changes that uncouple this shared fate can result in disease. In this way, looking to ecological and evolutionary principles might provide new strategies for restoring and maintaining human health.}, author = {Dethlefsen, Les and McFall-Ngai, Margaret and Relman, David A.}, citeulike-article-id = {1794662}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nature06245}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nature06245}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/17943117}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=17943117}, day = {17}, doi = {10.1038/nature06245}, issn = {0028-0836}, journal = {Nature}, keywords = {figure, landscape}, month = {October}, number = {7164}, pages = {811--818}, posted-at = {2008-08-19 13:35:48}, priority = {2}, publisher = {Nature Publishing Group}, title = {An ecological and evolutionary perspective on human\^{a}€“microbe mutualism and disease}, url = {http://dx.doi.org/10.1038/nature06245}, volume = {449}, year = {2007} }

TY - JOUR ID - citeulike:1794662 L3 - citeulike-article-id:1794662 N2 - The microbial communities of humans are characteristic and complex mixtures of microorganisms that have co-evolved with their human hosts. The species that make up these communities vary between hosts as a result of restricted migration of microorganisms between hosts and strong ecological interactions within hosts, as well as host variability in terms of diet, genotype and colonization history. The shared evolutionary fate of humans and their symbiotic bacteria has selected for mutualistic interactions that are essential for human health, and ecological or genetic changes that uncouple this shared fate can result in disease. In this way, looking to ecological and evolutionary principles might provide new strategies for restoring and maintaining human health. IS - 7164 JF - Nature SN - 0028-0836 EP - 818 TI - An ecological and evolutionary perspective on human–microbe mutualism and disease PB - Nature Publishing Group VL - 449 SP - 811 KW - figure KW - landscape AU - Dethlefsen, Les AU - McFall-Ngai, Margaret AU - Relman, David PY - 2007/10/17/ UR - http://dx.doi.org/10.1038/nature06245 ER -