Adapting Proteostasis for Disease Intervention Export

@article{citeulike:2426631, abstract = {The protein components of eukaryotic cells face acute and chronic challenges to their integrity. Eukaryotic protein homeostasis, or proteostasis, enables healthy cell and organismal development and aging and protects against disease. Here, we describe the proteostasis network, a set of interacting activities that maintain the health of proteome and the organism. Deficiencies in proteostasis lead to many metabolic, oncological, neurodegenerative, and cardiovascular disorders. Small-molecule or biological proteostasis regulators that manipulate the concentration, conformation, quaternary structure, and/or the location of protein(s) have the potential to ameliorate some of the most challenging diseases of our era. 10.1126/science.1141448}, author = {Balch, William E. and Morimoto, Richard I. and Dillin, Andrew and Kelly, Jeffery W.}, citeulike-article-id = {2426631}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1141448}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/319/5865/916}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18276881}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18276881}, comment = {Cell. 2008 Jul 25;134(2):204-6 Costly mistakes: translational infidelity and protein homeostasis. Powers ET, Balch WE.}, day = {15}, doi = {10.1126/science.1141448}, journal = {Science}, keywords = {evol\_med}, month = {February}, number = {5865}, pages = {916--919}, posted-at = {2008-09-08 10:11:39}, priority = {2}, title = {Adapting Proteostasis for Disease Intervention}, url = {http://dx.doi.org/10.1126/science.1141448}, volume = {319}, year = {2008} }

TY - JOUR ID - citeulike:2426631 L3 - citeulike-article-id:2426631 N2 - The protein components of eukaryotic cells face acute and chronic challenges to their integrity. Eukaryotic protein homeostasis, or proteostasis, enables healthy cell and organismal development and aging and protects against disease. Here, we describe the proteostasis network, a set of interacting activities that maintain the health of proteome and the organism. Deficiencies in proteostasis lead to many metabolic, oncological, neurodegenerative, and cardiovascular disorders. Small-molecule or biological proteostasis regulators that manipulate the concentration, conformation, quaternary structure, and/or the location of protein(s) have the potential to ameliorate some of the most challenging diseases of our era. 10.1126/science.1141448 IS - 5865 JF - Science EP - 919 TI - Adapting Proteostasis for Disease Intervention VL - 319 SP - 916 KW - evol_med N1 - Cell. 2008 Jul 25;134(2):204-6 Costly mistakes: translational infidelity and protein homeostasis. Powers ET, Balch WE. AU - Balch, William AU - Morimoto, Richard AU - Dillin, Andrew AU - Kelly, Jeffery PY - 2008/02/15/ UR - http://dx.doi.org/10.1126/science.1141448 ER -