Chance and necessity in chromosomal gene distributions Export

@article{citeulike:3000238, abstract = {By analyzing the spacing of genes on chromosomes, we find that transcriptional and RNA-processing regulatory sequences outside coding regions leave footprints on the distribution of intergenic distances. Using analogies between genes on chromosomes and one-dimensional gases, we constructed a statistical null model. We used this to estimate typical upstream and downstream regulatory sequence sizes in various species. Deviations from this model reveal bi-directional transcriptional regulatory regions in Saccharomyces cerevisiae and bi-directional terminators in Escherichia coli.}, address = {FOM Institute for Atomic and Molecular Physics, 1098 SJ, Amsterdam, The Netherlands. hermsen@amolf.nl}, author = {HERMSEN,, R and TENWOLDE,, P and TEICHMANN,, S}, citeulike-article-id = {3000238}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.tig.2008.02.004}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0168952508000814}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18378035}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18378035}, doi = {10.1016/j.tig.2008.02.004}, issn = {01689525}, journal = {Trends in Genetics}, keywords = {genome\_organisn}, month = {May}, number = {5}, pages = {216--219}, posted-at = {2008-07-14 21:47:29}, priority = {2}, title = {Chance and necessity in chromosomal gene distributions}, url = {http://dx.doi.org/10.1016/j.tig.2008.02.004}, volume = {24}, year = {2008} }

TY - JOUR ID - citeulike:3000238 L3 - citeulike-article-id:3000238 N2 - By analyzing the spacing of genes on chromosomes, we find that transcriptional and RNA-processing regulatory sequences outside coding regions leave footprints on the distribution of intergenic distances. Using analogies between genes on chromosomes and one-dimensional gases, we constructed a statistical null model. We used this to estimate typical upstream and downstream regulatory sequence sizes in various species. Deviations from this model reveal bi-directional transcriptional regulatory regions in Saccharomyces cerevisiae and bi-directional terminators in Escherichia coli. IS - 5 JF - Trends in Genetics SN - 01689525 AD - FOM Institute for Atomic and Molecular Physics, 1098 SJ, Amsterdam, The Netherlands. hermsen@amolf.nl EP - 219 TI - Chance and necessity in chromosomal gene distributions VL - 24 SP - 216 KW - genome_organisn AU - HERMSEN,, R AU - TENWOLDE,, P AU - TEICHMANN,, S PY - 2008/05// UR - http://dx.doi.org/10.1016/j.tig.2008.02.004 ER -