Codon reassignment and the evolving genetic code: problems and pitfalls in post-genome analysis.

@article{citeulike:3297835, abstract = {The in silico translation of open reading frames, using the 'universal genetic code', must be approached with caution. The uncovering of a number of codon reassignments in nuclear and organellar genomes highlights the importance of experimentally confirming the assignments of all 64 codons for the species whose genome is under investigation. Such alterations to codon meaning also suggest that the genetic code is not 'frozen' and continues to evolve.}, address = {Dept of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, UK.}, author = {O'Sullivan, J. M. and Davenport, J. B. and Tuite, M. F.}, citeulike-article-id = {3297835}, issn = {0168-9525}, journal = {Trends in genetics : TIG}, month = {January}, number = {1}, pages = {20--22}, posted-at = {2008-09-20 12:12:36}, priority = {2}, title = {Codon reassignment and the evolving genetic code: problems and pitfalls in post-genome analysis.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/11163917}, volume = {17}, year = {2001} }

TY - JOUR ID - citeulike:3297835 L3 - citeulike-article-id:3297835 N2 - The in silico translation of open reading frames, using the 'universal genetic code', must be approached with caution. The uncovering of a number of codon reassignments in nuclear and organellar genomes highlights the importance of experimentally confirming the assignments of all 64 codons for the species whose genome is under investigation. Such alterations to codon meaning also suggest that the genetic code is not 'frozen' and continues to evolve. IS - 1 JF - Trends in genetics : TIG SN - 0168-9525 AD - Dept of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, UK. EP - 22 TI - Codon reassignment and the evolving genetic code: problems and pitfalls in post-genome analysis. VL - 17 SP - 20 AU - O'Sullivan, JM AU - Davenport, JB AU - Tuite, MF PY - 2001/01// UR - http://view.ncbi.nlm.nih.gov/pubmed/11163917 ER -