Adaptive changes in the transcription factor HoxA-11 are essential for the evolution of pregnancy in mammals. Export

@article{citeulike:3332325, abstract = {Evolutionary change in gene regulation can result from changes in cis-regulatory elements, leading to differences in the temporal and spatial expression of genes or in the coding region of transcription factors leading to novel functions or both. Although there is a growing body of evidence supporting the importance of cis-regulatory evolution, examples of protein-mediated evolution of novel developmental pathways have not been demonstrated. Here, we investigate the evolution of prolactin (PRL) expression in endometrial cells, which is essential for placentation/pregnancy in eutherian mammals and is a direct regulatory target of the transcription factor HoxA-11. Here, we show that (i) endometrial PRL expression is a derived feature of placental mammals, (ii) the PRL regulatory gene HoxA-11 experienced a period of strong positive selection in the stem-lineage of eutherian mammals, and (iii) only HoxA-11 proteins from placental mammals, including the reconstructed ancestral eutherian gene, are able to up-regulate PRL from the promoter used in endometrial cells. In contrast, HoxA-11 from the reconstructed therian ancestor, opossum, platypus, and chicken are unable to up-regulate PRL expression. These results demonstrate that the evolution of novel gene expression domains is not only mediated by the evolution of cis-regulatory elements but can also require evolutionary changes of transcription factor proteins themselves.}, address = {Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT 06511;}, author = {Lynch, Vincent J J. and Tanzer, Andrea and Wang, Yajun and Leung, Frederick C C. and Gellersen, Birgit and Emera, Deena and Wagner, Gunter P P.}, citeulike-article-id = {3332325}, citeulike-linkout-0 = {http://dx.doi.org/10.1073/pnas.0802355105}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18809929}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18809929}, day = {22}, doi = {10.1073/pnas.0802355105}, issn = {1091-6490}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, keywords = {evo\_devo}, month = {September}, posted-at = {2008-09-24 16:15:33}, priority = {2}, title = {Adaptive changes in the transcription factor HoxA-11 are essential for the evolution of pregnancy in mammals.}, url = {http://dx.doi.org/10.1073/pnas.0802355105}, year = {2008} }

TY - JOUR ID - citeulike:3332325 L3 - citeulike-article-id:3332325 N2 - Evolutionary change in gene regulation can result from changes in cis-regulatory elements, leading to differences in the temporal and spatial expression of genes or in the coding region of transcription factors leading to novel functions or both. Although there is a growing body of evidence supporting the importance of cis-regulatory evolution, examples of protein-mediated evolution of novel developmental pathways have not been demonstrated. Here, we investigate the evolution of prolactin (PRL) expression in endometrial cells, which is essential for placentation/pregnancy in eutherian mammals and is a direct regulatory target of the transcription factor HoxA-11. Here, we show that (i) endometrial PRL expression is a derived feature of placental mammals, (ii) the PRL regulatory gene HoxA-11 experienced a period of strong positive selection in the stem-lineage of eutherian mammals, and (iii) only HoxA-11 proteins from placental mammals, including the reconstructed ancestral eutherian gene, are able to up-regulate PRL from the promoter used in endometrial cells. In contrast, HoxA-11 from the reconstructed therian ancestor, opossum, platypus, and chicken are unable to up-regulate PRL expression. These results demonstrate that the evolution of novel gene expression domains is not only mediated by the evolution of cis-regulatory elements but can also require evolutionary changes of transcription factor proteins themselves. JF - Proceedings of the National Academy of Sciences of the United States of America SN - 1091-6490 AD - Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT 06511; TI - Adaptive changes in the transcription factor HoxA-11 are essential for the evolution of pregnancy in mammals. KW - evo_devo AU - Lynch, Vincent J AU - Tanzer, Andrea AU - Wang, Yajun AU - Leung, Frederick C AU - Gellersen, Birgit AU - Emera, Deena AU - Wagner, Gunter P PY - 2008/09/22/ UR - http://dx.doi.org/10.1073/pnas.0802355105 ER -