Developmental Constraints on Vertebrate Genome Evolution Export

@article{citeulike:3812641, abstract = {Author Summary Because embryonic development must proceed correctly for an animal to survive, changes in evolution are constrained according to their effects on development. Changes that disrupt development too dramatically are thus rare in evolution. While this has been long observed at the morphological level, it has been more difficult to characterize the impact of such constraints on the genome. In this study, we investigate the effect of gene expression over vertebrate developmental time (from early to late development) on two main features: the gravity of mutation effects (i.e., is removal of the gene lethal?) and the propensity of the gene to remain in double copy after a duplication. We see that both features are consistent, in both zebrafish and mouse, in indicating a strong effect of constraints, which are progressively weaker towards late development, in early development on the genome.}, author = {Roux, Julien and Robinson-Rechavi, Marc}, citeulike-article-id = {3812641}, citeulike-linkout-0 = {http://dx.doi.org/10.1371/journal.pgen.1000311}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19096706}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19096706}, day = {19}, doi = {10.1371/journal.pgen.1000311}, journal = {PLoS Genet}, keywords = {duplicability}, month = {December}, number = {12}, pages = {e1000311+}, posted-at = {2008-12-28 13:59:26}, priority = {2}, publisher = {Public Library of Science}, title = {Developmental Constraints on Vertebrate Genome Evolution}, url = {http://dx.doi.org/10.1371/journal.pgen.1000311}, volume = {4}, year = {2008} }

TY - JOUR ID - citeulike:3812641 L3 - citeulike-article-id:3812641 N2 - Author Summary Because embryonic development must proceed correctly for an animal to survive, changes in evolution are constrained according to their effects on development. Changes that disrupt development too dramatically are thus rare in evolution. While this has been long observed at the morphological level, it has been more difficult to characterize the impact of such constraints on the genome. In this study, we investigate the effect of gene expression over vertebrate developmental time (from early to late development) on two main features: the gravity of mutation effects (i.e., is removal of the gene lethal?) and the propensity of the gene to remain in double copy after a duplication. We see that both features are consistent, in both zebrafish and mouse, in indicating a strong effect of constraints, which are progressively weaker towards late development, in early development on the genome. IS - 12 JF - PLoS Genet TI - Developmental Constraints on Vertebrate Genome Evolution PB - Public Library of Science VL - 4 SP - e1000311 KW - duplicability AU - Roux, Julien AU - Robinson-Rechavi, Marc PY - 2008/12/19/ UR - http://dx.doi.org/10.1371/journal.pgen.1000311 ER -