Comment on "Human-specific gain of function in a developmental enhancer". Export

@article{citeulike:4112557, abstract = {Prabhakar et al. (Reports, 5 September 2008, p. 1346) argued that the conserved noncoding sequence HACNS1 has undergone positive selection and contributed to human adaptation. However, the pattern of substitution in HACNS1 is more consistent with the neutral process of biased gene conversion (BGC). The reported human-specific gain of function is likely due to the accumulation of deleterious mutations driven by BGC, not positive selection.}, author = {Duret, Laurent and Galtier, Nicolas}, citeulike-article-id = {4112557}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1165848}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/323/5915/714c}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19197042}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19197042}, day = {6}, doi = {10.1126/science.1165848}, issn = {1095-9203}, journal = {Science (New York, N.Y.)}, keywords = {adaptation, bgc, cne}, month = {February}, number = {5915}, pages = {714c+}, posted-at = {2009-09-29 13:25:09}, priority = {2}, title = {Comment on "Human-specific gain of function in a developmental enhancer".}, url = {http://dx.doi.org/10.1126/science.1165848}, volume = {323}, year = {2009} }

TY - JOUR ID - citeulike:4112557 L3 - citeulike-article-id:4112557 N2 - Prabhakar et al. (Reports, 5 September 2008, p. 1346) argued that the conserved noncoding sequence HACNS1 has undergone positive selection and contributed to human adaptation. However, the pattern of substitution in HACNS1 is more consistent with the neutral process of biased gene conversion (BGC). The reported human-specific gain of function is likely due to the accumulation of deleterious mutations driven by BGC, not positive selection. IS - 5915 JF - Science (New York, N.Y.) SN - 1095-9203 TI - Comment on "Human-specific gain of function in a developmental enhancer". VL - 323 SP - 714c KW - adaptation KW - bgc KW - cne AU - Duret, Laurent AU - Galtier, Nicolas PY - 2009/02/06/ UR - http://dx.doi.org/10.1126/science.1165848 ER -