Unstable Tandem Repeats in Promoters Confer Transcriptional Evolvability Export

@article{citeulike:4674017, abstract = {Relative to most regions of the genome, tandemly repeated DNA sequences display a greater propensity to mutate. A search for tandem repeats in the Saccharomyces cerevisiae genome revealed that the nucleosome-free region directly upstream of genes (the promoter region) is enriched in repeats. As many as 25\% of all gene promoters contain tandem repeat sequences. Genes driven by these repeat-containing promoters show significantly higher rates of transcriptional divergence. Variations in repeat length result in changes in expression and local nucleosome positioning. Tandem repeats are variable elements in promoters that may facilitate evolutionary tuning of gene expression by affecting local chromatin structure. 10.1126/science.1170097}, author = {Vinces, Marcelo D. and Legendre, Matthieu and Caldara, Marina and Hagihara, Masaki and Verstrepen, Kevin J.}, booktitle = {Science}, citeulike-article-id = {4674017}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1170097}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/324/5931/1213?sa_campaign=Email}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19478187}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19478187}, day = {29}, doi = {10.1126/science.1170097}, issn = {1095-9203}, journal = {Science (New York, N.Y.)}, keywords = {evolution}, month = {May}, number = {5931}, pages = {1213--1216}, posted-at = {2009-06-12 17:27:48}, priority = {2}, title = {Unstable Tandem Repeats in Promoters Confer Transcriptional Evolvability}, url = {http://dx.doi.org/10.1126/science.1170097}, volume = {324}, year = {2009} }

TY - JOUR ID - citeulike:4674017 L3 - citeulike-article-id:4674017 N2 - Relative to most regions of the genome, tandemly repeated DNA sequences display a greater propensity to mutate. A search for tandem repeats in the Saccharomyces cerevisiae genome revealed that the nucleosome-free region directly upstream of genes (the promoter region) is enriched in repeats. As many as 25% of all gene promoters contain tandem repeat sequences. Genes driven by these repeat-containing promoters show significantly higher rates of transcriptional divergence. Variations in repeat length result in changes in expression and local nucleosome positioning. Tandem repeats are variable elements in promoters that may facilitate evolutionary tuning of gene expression by affecting local chromatin structure. 10.1126/science.1170097 IS - 5931 JF - Science (New York, N.Y.) SN - 1095-9203 EP - 1216 TI - Unstable Tandem Repeats in Promoters Confer Transcriptional Evolvability VL - 324 T2 - Science SP - 1213 KW - evolution AU - Vinces, Marcelo AU - Legendre, Matthieu AU - Caldara, Marina AU - Hagihara, Masaki AU - Verstrepen, Kevin PY - 2009/05/29/ UR - http://dx.doi.org/10.1126/science.1170097 ER -