Responses to hemorrhagic arterial pressure reduction in different ischemic renal failure models. Export

@article{citeulike:1335923, abstract = {Renal blood flow (RBF) autoregulation has been found to be impaired in both norepinephrine (NE) and renal artery clamp (RAC) rat ischemic acute renal failure models. However, the decline in RBF at the normal lower limit of autoregulation is greater in NE-ARF. The present study was designed to determine if this difference in autoregulatory profiles has potential functional and morphologic significance. After demonstrating a fall in RBF to renal perfusion pressure reduction to 90 mm Hg that was twofold more in one week NE- than RAC-ARF (p < 0.001), separate rats of both ischemic ARF types with nearly identical levels of azotemia and glomerular filtration rate reduction and sham-ARF rats were subjected to four-hour controlled reduction in mean arterial pressure to 90 by transient phlebotomy at one week. On day 9, two days after mean arterial pressure reduction, blood urea nitrogen (BUN), serum creatinine (SCr) and creatinine clearance (CCr) showed continued improvement in RAC-ARF, but there were significant increases in BUN (46 +/- 22 to 72 +/- 10 mg/dl) and SCr (1.2 +/- 0.2 to 1.5 +/- 0.2 mg/dl) and a decline in CCr (0.434 +/- 0.127 to 0.334 +/- 0.079 ml/min) in the NE-ARF group (all P < 0.02). The mean sum of scores of morphologic indices of ARF was higher in NE- than RAC-ARF kidneys of rats sacrificed on day 9 but interstitial edema was the only individual index that was worse in NE-ARF.(ABSTRACT TRUNCATED AT 250 WORDS)}, address = {University of Colorado Health Sciences Center, Denver.}, author = {Conger, J. D. and Schultz, M. F. and Miller, F. and Robinette, J. B.}, citeulike-article-id = {1335923}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/7967342}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=7967342}, issn = {0085-2538}, journal = {Kidney Int}, keywords = {arf}, month = {August}, number = {2}, pages = {318--323}, posted-at = {2007-05-26 23:21:50}, priority = {2}, title = {Responses to hemorrhagic arterial pressure reduction in different ischemic renal failure models.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/7967342}, volume = {46}, year = {1994} }

TY - JOUR ID - citeulike:1335923 L3 - citeulike-article-id:1335923 N2 - Renal blood flow (RBF) autoregulation has been found to be impaired in both norepinephrine (NE) and renal artery clamp (RAC) rat ischemic acute renal failure models. However, the decline in RBF at the normal lower limit of autoregulation is greater in NE-ARF. The present study was designed to determine if this difference in autoregulatory profiles has potential functional and morphologic significance. After demonstrating a fall in RBF to renal perfusion pressure reduction to 90 mm Hg that was twofold more in one week NE- than RAC-ARF (p < 0.001), separate rats of both ischemic ARF types with nearly identical levels of azotemia and glomerular filtration rate reduction and sham-ARF rats were subjected to four-hour controlled reduction in mean arterial pressure to 90 by transient phlebotomy at one week. On day 9, two days after mean arterial pressure reduction, blood urea nitrogen (BUN), serum creatinine (SCr) and creatinine clearance (CCr) showed continued improvement in RAC-ARF, but there were significant increases in BUN (46 +/- 22 to 72 +/- 10 mg/dl) and SCr (1.2 +/- 0.2 to 1.5 +/- 0.2 mg/dl) and a decline in CCr (0.434 +/- 0.127 to 0.334 +/- 0.079 ml/min) in the NE-ARF group (all P < 0.02). The mean sum of scores of morphologic indices of ARF was higher in NE- than RAC-ARF kidneys of rats sacrificed on day 9 but interstitial edema was the only individual index that was worse in NE-ARF.(ABSTRACT TRUNCATED AT 250 WORDS) IS - 2 JF - Kidney Int SN - 0085-2538 AD - University of Colorado Health Sciences Center, Denver. EP - 323 TI - Responses to hemorrhagic arterial pressure reduction in different ischemic renal failure models. VL - 46 SP - 318 KW - arf AU - Conger, JD AU - Schultz, MF AU - Miller, F AU - Robinette, JB PY - 1994/08// UR - http://view.ncbi.nlm.nih.gov/pubmed/7967342 ER -