Fludarabine treatment of cryoglobulinemic glomerulonephritis. Export

@article{citeulike:1339387, abstract = {Three patients (one hepatitis C positive) presented with renal insufficiency and nephrotic-range proteinuria resulting from mixed cryoglobulinemia and glomerulonephritis. All three patients received two to four cycles of intravenous fludarabine (each cycle consisted of 25 to 50 mg/d for 4 to 5 days). All patients responded to therapy with a decrease in proteinuria, increase in serum albumin, and decrease in serum creatinine. This response was evident by 2 months and persisted for 2 to 5 years. In two patients, this response was accompanied by disappearance of cryoglobulins, at least transiently. One patient developed tuberculosis with neutropenia. Transient blindness and neutropenia were seen in another patient. These results suggest that fludarabine may be a useful treatment in cryoglobulinemia with glomerulonephritis, although its use may be accompanied by side effects.}, address = {Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, NY, USA.}, author = {Rosenstock, J. L. and Stern, L. and Sherman, W. H. and Appel, G. B. and Radhakrishnan, J.}, citeulike-article-id = {1339387}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/12200818}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=12200818}, issn = {1523-6838}, journal = {Am J Kidney Dis}, keywords = {cryoglobulinemia}, month = {September}, number = {3}, pages = {644--648}, posted-at = {2007-05-28 22:07:51}, priority = {2}, title = {Fludarabine treatment of cryoglobulinemic glomerulonephritis.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/12200818}, volume = {40}, year = {2002} }

TY - JOUR ID - citeulike:1339387 L3 - citeulike-article-id:1339387 N2 - Three patients (one hepatitis C positive) presented with renal insufficiency and nephrotic-range proteinuria resulting from mixed cryoglobulinemia and glomerulonephritis. All three patients received two to four cycles of intravenous fludarabine (each cycle consisted of 25 to 50 mg/d for 4 to 5 days). All patients responded to therapy with a decrease in proteinuria, increase in serum albumin, and decrease in serum creatinine. This response was evident by 2 months and persisted for 2 to 5 years. In two patients, this response was accompanied by disappearance of cryoglobulins, at least transiently. One patient developed tuberculosis with neutropenia. Transient blindness and neutropenia were seen in another patient. These results suggest that fludarabine may be a useful treatment in cryoglobulinemia with glomerulonephritis, although its use may be accompanied by side effects. IS - 3 JF - Am J Kidney Dis SN - 1523-6838 AD - Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, NY, USA. EP - 648 TI - Fludarabine treatment of cryoglobulinemic glomerulonephritis. VL - 40 SP - 644 KW - cryoglobulinemia AU - Rosenstock, JL AU - Stern, L AU - Sherman, WH AU - Appel, GB AU - Radhakrishnan, J PY - 2002/09// UR - http://view.ncbi.nlm.nih.gov/pubmed/12200818 ER -