Spontaneous attentional fluctuations in impaired states and pathological conditions: A neurobiological hypothesis Export

@article{citeulike:3308777, abstract = {In traditional accounts, fluctuations in sustained and focused attention and associated attentional lapses during task performance are regarded as the result of failures of top-down and effortful higher order processes. The current paper reviews an alternative hypothesis: that spontaneous patterns of very low frequency inlMMLBox coherence within a specific brain network ('default-mode network') thought to support a pattern of generalized task-non-specific cognition during rest, can persist or intrude into periods of active task-specific processing, producing periodic fluctuations in attention that compete with goal-directed activity. We review recent studies supporting the existence of the resting state default network, examine the mechanism underpinning it, describe the consequent temporally distinctive effects on cognition and behaviour of default-mode interference into active processing periods, and suggest some factors that might predispose to it. Finally, we explore the putative role of default-mode interference as a cause of performance variability in attention deficit/hyperactivity disorder.}, address = {Developmental Brain \& Behaviour Unit, School of Psychology, University of Southampton, Southampton, UK. ejb3@soton.ac.uk}, author = {Sonugabarke, E. and Castellanos, F.}, citeulike-article-id = {3308777}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.neubiorev.2007.02.005}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S014976340700022X}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/17445893}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=17445893}, doi = {10.1016/j.neubiorev.2007.02.005}, issn = {01497634}, journal = {Neuroscience \& Biobehavioral Reviews}, keywords = {default\_network}, number = {7}, pages = {977--986}, posted-at = {2009-10-07 08:36:47}, priority = {5}, title = {Spontaneous attentional fluctuations in impaired states and pathological conditions: A neurobiological hypothesis}, url = {http://dx.doi.org/10.1016/j.neubiorev.2007.02.005}, volume = {31}, year = {2007} }

TY - JOUR ID - citeulike:3308777 L3 - citeulike-article-id:3308777 N2 - In traditional accounts, fluctuations in sustained and focused attention and associated attentional lapses during task performance are regarded as the result of failures of top-down and effortful higher order processes. The current paper reviews an alternative hypothesis: that spontaneous patterns of very low frequency inlMMLBox coherence within a specific brain network (‘default-mode network’) thought to support a pattern of generalized task-non-specific cognition during rest, can persist or intrude into periods of active task-specific processing, producing periodic fluctuations in attention that compete with goal-directed activity. We review recent studies supporting the existence of the resting state default network, examine the mechanism underpinning it, describe the consequent temporally distinctive effects on cognition and behaviour of default-mode interference into active processing periods, and suggest some factors that might predispose to it. Finally, we explore the putative role of default-mode interference as a cause of performance variability in attention deficit/hyperactivity disorder. IS - 7 JF - Neuroscience & Biobehavioral Reviews SN - 01497634 AD - Developmental Brain & Behaviour Unit, School of Psychology, University of Southampton, Southampton, UK. ejb3@soton.ac.uk EP - 986 TI - Spontaneous attentional fluctuations in impaired states and pathological conditions: A neurobiological hypothesis VL - 31 SP - 977 KW - default_network AU - Sonugabarke, E AU - Castellanos, F PY - 2007/// UR - http://dx.doi.org/10.1016/j.neubiorev.2007.02.005 ER -