Lateral habenula as a source of negative reward signals in dopamine neurons. Export

@article{citeulike:1323454, abstract = {Midbrain dopamine neurons are key components of the brain's reward system, which is thought to guide reward-seeking behaviours. Although recent studies have shown how dopamine neurons respond to rewards and sensory stimuli predicting reward, it is unclear which parts of the brain provide dopamine neurons with signals necessary for these actions. Here we show that the primate lateral habenula, part of the structure called the epithalamus, is a major candidate for a source of negative reward-related signals in dopamine neurons. We recorded the activity of habenula neurons and dopamine neurons while rhesus monkeys were performing a visually guided saccade task with positionally biased reward outcomes. Many habenula neurons were excited by a no-reward-predicting target and inhibited by a reward-predicting target. In contrast, dopamine neurons were excited and inhibited by reward-predicting and no-reward-predicting targets, respectively. Each time the rewarded and unrewarded positions were reversed, both habenula and dopamine neurons reversed their responses as the bias in saccade latency reversed. In unrewarded trials, the excitation of habenula neurons started earlier than the inhibition of dopamine neurons. Furthermore, weak electrical stimulation of the lateral habenula elicited strong inhibitions in dopamine neurons. These results suggest that the inhibitory input from the lateral habenula plays an important role in determining the reward-related activity of dopamine neurons.}, author = {Matsumoto, Masayuki and Hikosaka, Okihide}, citeulike-article-id = {1323454}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nature05860}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nature05860}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/17522629}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=17522629}, day = {28}, doi = {10.1038/nature05860}, issn = {1476-4687}, journal = {Nature}, keywords = {1dr, aversive, dopamine, habenula, rpe}, month = {June}, number = {7148}, pages = {1111--1115}, posted-at = {2007-05-25 17:38:33}, priority = {2}, publisher = {Nature Publishing Group}, title = {Lateral habenula as a source of negative reward signals in dopamine neurons.}, url = {http://dx.doi.org/10.1038/nature05860}, volume = {447}, year = {2007} }

TY - JOUR ID - citeulike:1323454 L3 - citeulike-article-id:1323454 N2 - Midbrain dopamine neurons are key components of the brain's reward system, which is thought to guide reward-seeking behaviours. Although recent studies have shown how dopamine neurons respond to rewards and sensory stimuli predicting reward, it is unclear which parts of the brain provide dopamine neurons with signals necessary for these actions. Here we show that the primate lateral habenula, part of the structure called the epithalamus, is a major candidate for a source of negative reward-related signals in dopamine neurons. We recorded the activity of habenula neurons and dopamine neurons while rhesus monkeys were performing a visually guided saccade task with positionally biased reward outcomes. Many habenula neurons were excited by a no-reward-predicting target and inhibited by a reward-predicting target. In contrast, dopamine neurons were excited and inhibited by reward-predicting and no-reward-predicting targets, respectively. Each time the rewarded and unrewarded positions were reversed, both habenula and dopamine neurons reversed their responses as the bias in saccade latency reversed. In unrewarded trials, the excitation of habenula neurons started earlier than the inhibition of dopamine neurons. Furthermore, weak electrical stimulation of the lateral habenula elicited strong inhibitions in dopamine neurons. These results suggest that the inhibitory input from the lateral habenula plays an important role in determining the reward-related activity of dopamine neurons. IS - 7148 JF - Nature SN - 1476-4687 EP - 1115 TI - Lateral habenula as a source of negative reward signals in dopamine neurons. PB - Nature Publishing Group VL - 447 SP - 1111 KW - 1dr KW - aversive KW - dopamine KW - habenula KW - rpe AU - Matsumoto, Masayuki AU - Hikosaka, Okihide PY - 2007/06/28/ UR - http://dx.doi.org/10.1038/nature05860 ER -