Corelease of dopamine and serotonin from striatal dopamine terminals. Export

@article{citeulike:346491, abstract = {The striatum receives rich dopaminergic and more moderate serotonergic innervation. After vesicular release, dopamine and serotonin (5-hydroxytryptamine, 5-HT) signaling is controlled by transporter-mediated reuptake. Dopamine is taken up by dopamine transporters (DATs), which are expressed at the highest density in the striatum. Although DATs also display a low affinity for 5-HT, that neurotransmitter is normally efficiently taken up by the 5-HT transporters. We found that when extracellular 5-HT is elevated by exogenous application or by using antidepressants (e.g., fluoxetine) to inhibit the 5-HT transporters, the extremely dense striatal DATs uptake 5-HT into dopamine terminals. Immunohistochemical results and measurements using fast cyclic voltammetry showed that elevated 5-HT is taken up by DATs into striatal dopamine terminals that subsequently release 5-HT and dopamine together. These results suggest that antidepressants that block serotonin transporters or other factors that elevate extracellular 5-HT alter the temporal and spatial relationship between dopamine and 5-HT signaling in the striatum.}, address = {Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA.}, author = {Zhou, F. M. and Liang, Y. and Salas, R. and Zhang, L. and De Biasi, M. and Dani, J. A.}, citeulike-article-id = {346491}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.neuron.2005.02.010}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/15820694}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=15820694}, day = {7}, doi = {10.1016/j.neuron.2005.02.010}, issn = {0896-6273}, journal = {Neuron}, keywords = {5-ht, antidepressant, dat, dopamine, serotonin, ssri, striatum}, month = {April}, number = {1}, pages = {65--74}, posted-at = {2005-10-09 23:02:05}, priority = {2}, title = {Corelease of dopamine and serotonin from striatal dopamine terminals.}, url = {http://dx.doi.org/10.1016/j.neuron.2005.02.010}, volume = {46}, year = {2005} }

TY - JOUR ID - citeulike:346491 L3 - citeulike-article-id:346491 N2 - The striatum receives rich dopaminergic and more moderate serotonergic innervation. After vesicular release, dopamine and serotonin (5-hydroxytryptamine, 5-HT) signaling is controlled by transporter-mediated reuptake. Dopamine is taken up by dopamine transporters (DATs), which are expressed at the highest density in the striatum. Although DATs also display a low affinity for 5-HT, that neurotransmitter is normally efficiently taken up by the 5-HT transporters. We found that when extracellular 5-HT is elevated by exogenous application or by using antidepressants (e.g., fluoxetine) to inhibit the 5-HT transporters, the extremely dense striatal DATs uptake 5-HT into dopamine terminals. Immunohistochemical results and measurements using fast cyclic voltammetry showed that elevated 5-HT is taken up by DATs into striatal dopamine terminals that subsequently release 5-HT and dopamine together. These results suggest that antidepressants that block serotonin transporters or other factors that elevate extracellular 5-HT alter the temporal and spatial relationship between dopamine and 5-HT signaling in the striatum. IS - 1 JF - Neuron SN - 0896-6273 AD - Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA. EP - 74 TI - Corelease of dopamine and serotonin from striatal dopamine terminals. VL - 46 SP - 65 KW - 5-ht KW - antidepressant KW - dat KW - dopamine KW - serotonin KW - ssri KW - striatum AU - Zhou, FM AU - Liang, Y AU - Salas, R AU - Zhang, L AU - De Biasi, M AU - Dani, JA PY - 2005/04/07/ UR - http://dx.doi.org/10.1016/j.neuron.2005.02.010 ER -