The coming age of complete, accurate, and ubiquitous proteomes.
High-resolution mass spectrometry (MS)-based proteomics has progressed tremendously over the years. For model organisms like yeast, we can now quantify complete proteomes in just a few hours. Developments discussed in this Perspective will soon enable complete proteome analysis of mammalian cells, as well, with profound impact on biology and biomedicine. Copyright © 2013 Elsevier Inc. All rights reserved.