Systematic comparison of the human saliva and plasma proteomes Export

@article{citeulike:6095121, abstract = {The proteome of human salivary fluid has the potential to open new doors for disease biomarker discovery. A recent study to comprehensively identify and catalog the human ductal salivary proteome led to the compilation of 1166 proteins. The protein complexity of both saliva and plasma is large, suggesting that a comparison of these two proteomes will provide valuable insight into their physiological significance and an understanding of the unique and overlapping disease diagnostic potential that each fluid provides. To create a more comprehensive catalog of human salivary proteins, we have first compiled an extensive list of proteins from whole saliva (WS) identified through MS experiments. The WS list is thereafter combined with the proteins identified from the ductal parotid, and submandibular and sublingual (parotid/SMSL) salivas. In parallel, a core dataset of the human plasma proteome with 3020 protein identifications was recently released. A total of 1939 nonredundant salivary proteins were compiled from a total of 19 474 unique peptide sequences identified from whole and ductal salivas; 740 out of the total 1939 salivary proteins were identified in both whole and ductal saliva. A total of 597 of the salivary proteins have been observed in plasma. Gene ontology (GO) analysis showed similarities in the distributions of the saliva and plasma proteomes with regard to cellular localization, biological processes, and molecular function, but revealed differences which may be related to the different physiological functions of saliva and plasma. The comprehensive catalog of the salivary proteome and its comparison to the plasma proteome provides insights useful for future study, such as exploration of potential biomarkers for disease diagnostics.}, address = {Department of Chemistry and Biochemistry, University of California-Los Angeles, Los Angeles, CA, USA; EMBL Outstation, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK; Calibrant Biosystems, Gaithersburg, MD, USA; Biomarkers and Systems Biology Center, Research Triangle Institute, Research Triangle, NC, USA; UCLA School of Dentistry and UCLA Dental Research Institute, University of California-Los Angeles, Los Angeles, CA, USA; Department of Chemistry and Biochemistry, University of Maryland, College Park, MD, USA; Center for Oral Biology, University of Rochester Medical Center, Rochester, NY, USA; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA; College of Dentistry, New York University, New York, NY, USA; Departments of Medicine and Genetics and Center for Computational Medicine and Biology, University of Michigan, Ann Arbor, MI, USA; Division of Pulmonary and Critical Care Medicine, University of Southern California, Los Angeles, CA, USA; Department of Oral Medicine, Diagnosis, and Radiology, School of Dentistry, University of Minnesota, Minneapolis, MN, USA; Scripps Research Institute, La Jolla, CA, USA; Department of Biological Chemistry, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, USA}, author = {Yan, Weihong and Apweiler, Rolf and Balgley, Brian M. and Boontheung, Pinmanee and Bundy, Jonathan L. and Cargile, Benjamin J. and Cole, Steve and Fang, Xueping and Gonzalez-Begne, Mireya and Griffin, Timothy J. and Hagen, Fred and Hu, Shen and Wolinsky, Lawrence E. and Lee, Cheng S. and Malamud, Daniel and Melvin, James E. and Menon, Rajasree and Mueller, Michael and Qiao, Renli and Rhodus, Nelson L. and Sevinsky, Joel R. and States, David and Stephenson, James L. and Than, Shawn and Yates, John R. and Yu, Weixia and Xie, Hongwei and Xie, Yongming and Omenn, Gilbert S. and Loo, Joseph A. and Wong, David T.}, citeulike-article-id = {6095121}, citeulike-linkout-0 = {http://dx.doi.org/10.1002/prca.200800140}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19898684}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19898684}, citeulike-linkout-3 = {http://www3.interscience.wiley.com/cgi-bin/abstract/121544711/ABSTRACT}, day = {1}, doi = {10.1002/prca.200800140}, issn = {1862-8354}, journal = {PROTEOMICS - CLINICAL APPLICATIONS}, keywords = {fluid, plasma, proteomics}, month = {January}, number = {1}, pages = {116--134}, posted-at = {2009-11-10 15:45:17}, priority = {2}, title = {Systematic comparison of the human saliva and plasma proteomes}, url = {http://dx.doi.org/10.1002/prca.200800140}, volume = {3}, year = {2009} }

TY - JOUR ID - citeulike:6095121 L3 - citeulike-article-id:6095121 N2 - The proteome of human salivary fluid has the potential to open new doors for disease biomarker discovery. A recent study to comprehensively identify and catalog the human ductal salivary proteome led to the compilation of 1166 proteins. The protein complexity of both saliva and plasma is large, suggesting that a comparison of these two proteomes will provide valuable insight into their physiological significance and an understanding of the unique and overlapping disease diagnostic potential that each fluid provides. To create a more comprehensive catalog of human salivary proteins, we have first compiled an extensive list of proteins from whole saliva (WS) identified through MS experiments. The WS list is thereafter combined with the proteins identified from the ductal parotid, and submandibular and sublingual (parotid/SMSL) salivas. In parallel, a core dataset of the human plasma proteome with 3020 protein identifications was recently released. A total of 1939 nonredundant salivary proteins were compiled from a total of 19 474 unique peptide sequences identified from whole and ductal salivas; 740 out of the total 1939 salivary proteins were identified in both whole and ductal saliva. A total of 597 of the salivary proteins have been observed in plasma. Gene ontology (GO) analysis showed similarities in the distributions of the saliva and plasma proteomes with regard to cellular localization, biological processes, and molecular function, but revealed differences which may be related to the different physiological functions of saliva and plasma. The comprehensive catalog of the salivary proteome and its comparison to the plasma proteome provides insights useful for future study, such as exploration of potential biomarkers for disease diagnostics. IS - 1 JF - PROTEOMICS - CLINICAL APPLICATIONS SN - 1862-8354 AD - Department of Chemistry and Biochemistry, University of California-Los Angeles, Los Angeles, CA, USA; EMBL Outstation, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK; Calibrant Biosystems, Gaithersburg, MD, USA; Biomarkers and Systems Biology Center, Research Triangle Institute, Research Triangle, NC, USA; UCLA School of Dentistry and UCLA Dental Research Institute, University of California-Los Angeles, Los Angeles, CA, USA; Department of Chemistry and Biochemistry, University of Maryland, College Park, MD, USA; Center for Oral Biology, University of Rochester Medical Center, Rochester, NY, USA; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA; College of Dentistry, New York University, New York, NY, USA; Departments of Medicine and Genetics and Center for Computational Medicine and Biology, University of Michigan, Ann Arbor, MI, USA; Division of Pulmonary and Critical Care Medicine, University of Southern California, Los Angeles, CA, USA; Department of Oral Medicine, Diagnosis, and Radiology, School of Dentistry, University of Minnesota, Minneapolis, MN, USA; Scripps Research Institute, La Jolla, CA, USA; Department of Biological Chemistry, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, USA EP - 134 TI - Systematic comparison of the human saliva and plasma proteomes VL - 3 SP - 116 KW - fluid KW - plasma KW - proteomics AU - Yan, Weihong AU - Apweiler, Rolf AU - Balgley, Brian AU - Boontheung, Pinmanee AU - Bundy, Jonathan AU - Cargile, Benjamin AU - Cole, Steve AU - Fang, Xueping AU - Gonzalez-Begne, Mireya AU - Griffin, Timothy AU - Hagen, Fred AU - Hu, Shen AU - Wolinsky, Lawrence AU - Lee, Cheng AU - Malamud, Daniel AU - Melvin, James AU - Menon, Rajasree AU - Mueller, Michael AU - Qiao, Renli AU - Rhodus, Nelson AU - Sevinsky, Joel AU - States, David AU - Stephenson, James AU - Than, Shawn AU - Yates, John AU - Yu, Weixia AU - Xie, Hongwei AU - Xie, Yongming AU - Omenn, Gilbert AU - Loo, Joseph AU - Wong, David PY - 2009/01/01/ UR - http://dx.doi.org/10.1002/prca.200800140 ER -