Reentry in heterogeneous cardiac tissue described by the Luo-Rudy ventricular action potential model. Export

@article{citeulike:401451, abstract = {Heterogeneity of cardiac tissue is an important factor determining the initiation and dynamics of cardiac arrhythmias. In this paper, we studied the effects of gradients of electrophysiological heterogeneity on reentrant excitation patterns using computer simulations. We investigated the dynamics of spiral waves in a two-dimensional sheet of cardiac tissue described by the Luo-Rudy phase 1 (LR1) ventricular action potential model. A gradient of action potential duration (APD) was imposed by gradually varying the local current density of K(+) current or inward rectifying K(+) current along one axis of the tissue sheet. We show that a gradient of APD resulted in spiral wave drift. This drift consisted of two components. The longitudinal (along the gradient) component was always directed toward regions of longer spiral wave period. The transverse (perpendicular to the gradient) component had a direction dependent on the direction of rotation of the spiral wave. We estimated the velocity of the drift as a function of the magnitude of the gradient and discuss its implications.}, address = {Department of Theoretical Biology, Utrecht University, The Netherlands. khwjtuss@hotmail.com}, author = {Ten Tusscher, K. H. and Panfilov, A. V.}, citeulike-article-id = {401451}, citeulike-linkout-0 = {http://dx.doi.org/10.1152/ajpheart.00608.2002}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/12388228}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=12388228}, doi = {10.1152/ajpheart.00608.2002}, issn = {0363-6135}, journal = {Am J Physiol Heart Circ Physiol}, keywords = {action\_potential, ap, cardiac, drift, electrophysiology, heart, heterogeneity, lr, reentry, spiral\_wave, ventricles}, month = {February}, number = {2}, posted-at = {2005-11-20 14:58:57}, priority = {0}, title = {Reentry in heterogeneous cardiac tissue described by the Luo-Rudy ventricular action potential model.}, url = {http://dx.doi.org/10.1152/ajpheart.00608.2002}, volume = {284}, year = {2003} }

TY - JOUR ID - citeulike:401451 L3 - citeulike-article-id:401451 N2 - Heterogeneity of cardiac tissue is an important factor determining the initiation and dynamics of cardiac arrhythmias. In this paper, we studied the effects of gradients of electrophysiological heterogeneity on reentrant excitation patterns using computer simulations. We investigated the dynamics of spiral waves in a two-dimensional sheet of cardiac tissue described by the Luo-Rudy phase 1 (LR1) ventricular action potential model. A gradient of action potential duration (APD) was imposed by gradually varying the local current density of K(+) current or inward rectifying K(+) current along one axis of the tissue sheet. We show that a gradient of APD resulted in spiral wave drift. This drift consisted of two components. The longitudinal (along the gradient) component was always directed toward regions of longer spiral wave period. The transverse (perpendicular to the gradient) component had a direction dependent on the direction of rotation of the spiral wave. We estimated the velocity of the drift as a function of the magnitude of the gradient and discuss its implications. IS - 2 JF - Am J Physiol Heart Circ Physiol SN - 0363-6135 AD - Department of Theoretical Biology, Utrecht University, The Netherlands. khwjtuss@hotmail.com TI - Reentry in heterogeneous cardiac tissue described by the Luo-Rudy ventricular action potential model. VL - 284 KW - action_potential KW - ap KW - cardiac KW - drift KW - electrophysiology KW - heart KW - heterogeneity KW - lr KW - reentry KW - spiral_wave KW - ventricles AU - Ten Tusscher, KH AU - Panfilov, AV PY - 2003/02// UR - http://dx.doi.org/10.1152/ajpheart.00608.2002 ER -