Evidence for Cardiomyocyte Renewal in Humans Export

@article{citeulike:4264588, abstract = {It has been difficult to establish whether we are limited to the heart muscle cells we are born with or if cardiomyocytes are generated also later in life. We have taken advantage of the integration of carbon-14, generated by nuclear bomb tests during the Cold War, into DNA to establish the age of cardiomyocytes in humans. We report that cardiomyocytes renew, with a gradual decrease from 1\% turning over annually at the age of 25 to 0.45\% at the age of 75. Fewer than 50\% of cardiomyocytes are exchanged during a normal life span. The capacity to generate cardiomyocytes in the adult human heart suggests that it may be rational to work toward the development of therapeutic strategies aimed at stimulating this process in cardiac pathologies. 10.1126/science.1164680}, author = {Bergmann, Olaf and Bhardwaj, Ratan D. and Bernard, Samuel and Zdunek, Sofia and Barnabe-Heider, Fanie and Walsh, Stuart and Zupicich, Joel and Alkass, Kanar and Buchholz, Bruce A. and Druid, Henrik and Jovinge, Stefan and Frisen, Jonas}, citeulike-article-id = {4264588}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1164680}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/324/5923/98}, day = {3}, doi = {10.1126/science.1164680}, journal = {Science}, month = {April}, number = {5923}, pages = {98--102}, posted-at = {2009-04-03 15:00:04}, priority = {4}, title = {Evidence for Cardiomyocyte Renewal in Humans}, url = {http://dx.doi.org/10.1126/science.1164680}, volume = {324}, year = {2009} }

TY - JOUR ID - citeulike:4264588 L3 - citeulike-article-id:4264588 N2 - It has been difficult to establish whether we are limited to the heart muscle cells we are born with or if cardiomyocytes are generated also later in life. We have taken advantage of the integration of carbon-14, generated by nuclear bomb tests during the Cold War, into DNA to establish the age of cardiomyocytes in humans. We report that cardiomyocytes renew, with a gradual decrease from 1% turning over annually at the age of 25 to 0.45% at the age of 75. Fewer than 50% of cardiomyocytes are exchanged during a normal life span. The capacity to generate cardiomyocytes in the adult human heart suggests that it may be rational to work toward the development of therapeutic strategies aimed at stimulating this process in cardiac pathologies. 10.1126/science.1164680 IS - 5923 JF - Science EP - 102 TI - Evidence for Cardiomyocyte Renewal in Humans VL - 324 SP - 98 AU - Bergmann, Olaf AU - Bhardwaj, Ratan AU - Bernard, Samuel AU - Zdunek, Sofia AU - Barnabe-Heider, Fanie AU - Walsh, Stuart AU - Zupicich, Joel AU - Alkass, Kanar AU - Buchholz, Bruce AU - Druid, Henrik AU - Jovinge, Stefan AU - Frisen, Jonas PY - 2009/04/03/ UR - http://dx.doi.org/10.1126/science.1164680 ER -