Early time course of myocardial electrical impedance during acute coronary artery occlusion in pigs, dogs, and humans. Export

@article{citeulike:437202, abstract = {Changes in myocardial electrical impedance (MEI) and physiological end points have been correlated during acute ischemia. However, the importance of MEI's early time course is not clear. This study evaluates such significance, by comparing the temporal behavior of MEI during acute total occlusion of the left anterior descending coronary artery in anesthetized humans, dogs, and pigs. Here, interspecies differences in three MEI parameters (baseline, time to plateau onset, and plateau value normalized by baseline) were evaluated using Kruskal-Wallis ANOVA and post hoc tests (P < 0.05). Noteworthy differences in the MEI time to plateau onset were observed: In dogs, MEI ischemic plateau was reached after 46.3 min (SD 12.9) min of occlusion, a significantly longer period compared with that of pigs and humans [4.7 (SD 1.2) and 4.1 min (SD 1.9), respectively]. However, no differences could be observed between both animal species regarding the normalized MEI ischemic plateau value (15.3\% (SD 4.7) in pigs, vs. 19.6\% (SD 2.6) in dogs). For all studied MEI parameters, only swine values resembled those of humans. The severity of myocardial supply ischemia, resulting from coronary artery occlusion, is known to be dependent on collateral flow. Thus, because dogs possess a well-developed collateral system (unlike humans or pigs), they have shown superior resistance to occlusion of a coronary artery. Here, the early MEI time course after left anterior descending coronary artery occlusion, represented by the time required to reach ischemic plateau, was proven to reflect such interspecies differences.}, address = {Department of Anesthesiology, The Ohio State University, Columbus, 43210, USA. del-rio.4@osu.edu}, author = {del Rio, C. L. and McConnell, P. I. and Clymer, B. D. and Dzwonczyk, R. and Michler, R. E. and Billman, G. E. and Howie, M. B.}, citeulike-article-id = {437202}, citeulike-linkout-0 = {http://dx.doi.org/10.1152/japplphysiol.00830.2004}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/15961608}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=15961608}, doi = {10.1152/japplphysiol.00830.2004}, issn = {8750-7587}, journal = {J Appl Physiol}, keywords = {acute, artery, canine, dog, electricity, heart, human, impedance, myocardium, occlusion, pig, porcine}, month = {October}, number = {4}, pages = {1576--1581}, posted-at = {2005-12-14 04:29:26}, priority = {4}, title = {Early time course of myocardial electrical impedance during acute coronary artery occlusion in pigs, dogs, and humans.}, url = {http://dx.doi.org/10.1152/japplphysiol.00830.2004}, volume = {99}, year = {2005} }

TY - JOUR ID - citeulike:437202 L3 - citeulike-article-id:437202 N2 - Changes in myocardial electrical impedance (MEI) and physiological end points have been correlated during acute ischemia. However, the importance of MEI's early time course is not clear. This study evaluates such significance, by comparing the temporal behavior of MEI during acute total occlusion of the left anterior descending coronary artery in anesthetized humans, dogs, and pigs. Here, interspecies differences in three MEI parameters (baseline, time to plateau onset, and plateau value normalized by baseline) were evaluated using Kruskal-Wallis ANOVA and post hoc tests (P < 0.05). Noteworthy differences in the MEI time to plateau onset were observed: In dogs, MEI ischemic plateau was reached after 46.3 min (SD 12.9) min of occlusion, a significantly longer period compared with that of pigs and humans [4.7 (SD 1.2) and 4.1 min (SD 1.9), respectively]. However, no differences could be observed between both animal species regarding the normalized MEI ischemic plateau value (15.3% (SD 4.7) in pigs, vs. 19.6% (SD 2.6) in dogs). For all studied MEI parameters, only swine values resembled those of humans. The severity of myocardial supply ischemia, resulting from coronary artery occlusion, is known to be dependent on collateral flow. Thus, because dogs possess a well-developed collateral system (unlike humans or pigs), they have shown superior resistance to occlusion of a coronary artery. Here, the early MEI time course after left anterior descending coronary artery occlusion, represented by the time required to reach ischemic plateau, was proven to reflect such interspecies differences. IS - 4 JF - J Appl Physiol SN - 8750-7587 AD - Department of Anesthesiology, The Ohio State University, Columbus, 43210, USA. del-rio.4@osu.edu EP - 1581 TI - Early time course of myocardial electrical impedance during acute coronary artery occlusion in pigs, dogs, and humans. VL - 99 SP - 1576 KW - acute KW - artery KW - canine KW - dog KW - electricity KW - heart KW - human KW - impedance KW - myocardium KW - occlusion KW - pig KW - porcine AU - del Rio, CL AU - McConnell, PI AU - Clymer, BD AU - Dzwonczyk, R AU - Michler, RE AU - Billman, GE AU - Howie, MB PY - 2005/10// UR - http://dx.doi.org/10.1152/japplphysiol.00830.2004 ER -