Virtual electrodes in cardiac tissue: a common mechanism for anodal and cathodal stimulation. Export

@article{citeulike:532515, abstract = {Traditional cable analyses cannot explain complex patterns of excitation in cardiac tissue with unipolar, extracellular anodal, or cathodal stimuli. Epifluorescence imaging of the transmembrane potential during and after stimulation of both refractory and excitable tissue shows distinctive regions of simultaneous depolarization and hyperpolarization during stimulation that act as virtual cathodes and anodes. The results confirm bidomain model predictions that the onset (make) of a stimulus induces propagation from the virtual cathode, whereas stimulus termination (break) induces it from the virtual anode. In make stimulation, the virtual anode can delay activation of the underlying tissue, whereas in break stimulation this occurs under the virtual cathode. Thus make and break stimulations in cardiac tissue have a common mechanism that is the result of differences in the electrical anisotropy of the intracellular and extracellular spaces and provides clear proof of the validity of the bidomain model.}, address = {Department of Physics and Astronomy, Vanderbilt University, Nashville, Tennessee 37235, USA. wikswojp/ctrvax.vanderbilt.edu}, author = {Wikswo, J. P. and Lin, S. F. and Abbas, R. A.}, citeulike-article-id = {532515}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/8599628}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=8599628}, issn = {0006-3495}, journal = {Biophys J}, keywords = {aha, cardiac, electrophysiology, fellowship, heart, mechanism, octwedge, stimulation, tissue, vep, virtual\_electrodes}, month = {December}, number = {6}, pages = {2195--2210}, posted-at = {2006-03-12 19:47:56}, priority = {4}, title = {Virtual electrodes in cardiac tissue: a common mechanism for anodal and cathodal stimulation.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/8599628}, volume = {69}, year = {1995} }

TY - JOUR ID - citeulike:532515 L3 - citeulike-article-id:532515 N2 - Traditional cable analyses cannot explain complex patterns of excitation in cardiac tissue with unipolar, extracellular anodal, or cathodal stimuli. Epifluorescence imaging of the transmembrane potential during and after stimulation of both refractory and excitable tissue shows distinctive regions of simultaneous depolarization and hyperpolarization during stimulation that act as virtual cathodes and anodes. The results confirm bidomain model predictions that the onset (make) of a stimulus induces propagation from the virtual cathode, whereas stimulus termination (break) induces it from the virtual anode. In make stimulation, the virtual anode can delay activation of the underlying tissue, whereas in break stimulation this occurs under the virtual cathode. Thus make and break stimulations in cardiac tissue have a common mechanism that is the result of differences in the electrical anisotropy of the intracellular and extracellular spaces and provides clear proof of the validity of the bidomain model. IS - 6 JF - Biophys J SN - 0006-3495 AD - Department of Physics and Astronomy, Vanderbilt University, Nashville, Tennessee 37235, USA. wikswojp/ctrvax.vanderbilt.edu EP - 2210 TI - Virtual electrodes in cardiac tissue: a common mechanism for anodal and cathodal stimulation. VL - 69 SP - 2195 KW - aha KW - cardiac KW - electrophysiology KW - fellowship KW - heart KW - mechanism KW - octwedge KW - stimulation KW - tissue KW - vep KW - virtual_electrodes AU - Wikswo, JP AU - Lin, SF AU - Abbas, RA PY - 1995/12// UR - http://view.ncbi.nlm.nih.gov/pubmed/8599628 ER -