Magnesium intake and plasma concentrations of markers of systemic inflammation and endothelial dysfunction in women Export

@article{citeulike:1925935, abstract = {Background:Relations between magnesium intake and systemic inflammation and endothelial dysfunction are not well established. Objective:The aim of the present study was to examine whether and to what extent magnesium intake is related to inflammatory and endothelial markers. Design:We conducted a cross-sectional study of 657 women from the Nurses' Health Study cohort who were aged 43-69 y and free of cardiovascular disease, cancer, and diabetes mellitus when blood was drawn in 1989 and 1990. Plasma concentrations of C-reactive protein (CRP), interleukin 6 (IL-6), soluble tumor necrosis factor {alpha} receptor 2 (sTNF-R2), E-selectin, soluble intercellular adhesion molecule 1 (sICAM-1), and soluble vascular cell adhesion molecule 1 (sVCAM-1) were measured. Estimates from 2 semiquantitative food-frequency questionnaires, administered in 1986 and 1990, were averaged to assess dietary intakes. Results:In age-adjusted linear regression analyses, magnesium intake was inversely associated with plasma concentrations of CRP (P for linear trend = 0.003), E-selectin (P = 0.001), and sICAM-1 (P = 0.03). After further adjustment for physical activity, smoking status, alcohol use, postmenopausal hormone use, and body mass index, dietary magnesium intake remained inversely associated with CRP and E-selectin. Multivariate-adjusted geometric means for women in the highest quintile of dietary magnesium intake were 24\% lower for CRP (1.70 {+/-} 0.18 compared with 1.30 {+/-} 0.10 mg/dL; P for trend = 0.03) and 14\% lower for E-selectin (48.5 {+/-} 1.84 compared with 41.9 {+/-} 1.58 ng/mL; P for trend = 0.01) than those for women in the lowest quintile. Conclusion:Magnesium intake from diet is modestly and inversely associated with some but not all markers of systematic inflammation and endothelial dysfunction in apparently healthy women.}, author = {Song, Yiqing and Li, Tricia Y. and van Dam, Rob M. and Manson, Joann E. and Hu, Frank B.}, citeulike-article-id = {1925935}, citeulike-linkout-0 = {http://www.ajcn.org/cgi/content/abstract/85/4/1068}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17413107}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17413107}, day = {1}, journal = {Am J Clin Nutr}, keywords = {dietary, endothelial, magnesium}, month = {April}, number = {4}, pages = {1068--1074}, posted-at = {2007-11-16 10:27:18}, priority = {2}, title = {Magnesium intake and plasma concentrations of markers of systemic inflammation and endothelial dysfunction in women}, url = {http://www.ajcn.org/cgi/content/abstract/85/4/1068}, volume = {85}, year = {2007} }

TY - JOUR ID - citeulike:1925935 L3 - citeulike-article-id:1925935 N2 - Background:Relations between magnesium intake and systemic inflammation and endothelial dysfunction are not well established. Objective:The aim of the present study was to examine whether and to what extent magnesium intake is related to inflammatory and endothelial markers. Design:We conducted a cross-sectional study of 657 women from the Nurses' Health Study cohort who were aged 43-69 y and free of cardiovascular disease, cancer, and diabetes mellitus when blood was drawn in 1989 and 1990. Plasma concentrations of C-reactive protein (CRP), interleukin 6 (IL-6), soluble tumor necrosis factor {alpha} receptor 2 (sTNF-R2), E-selectin, soluble intercellular adhesion molecule 1 (sICAM-1), and soluble vascular cell adhesion molecule 1 (sVCAM-1) were measured. Estimates from 2 semiquantitative food-frequency questionnaires, administered in 1986 and 1990, were averaged to assess dietary intakes. Results:In age-adjusted linear regression analyses, magnesium intake was inversely associated with plasma concentrations of CRP (P for linear trend = 0.003), E-selectin (P = 0.001), and sICAM-1 (P = 0.03). After further adjustment for physical activity, smoking status, alcohol use, postmenopausal hormone use, and body mass index, dietary magnesium intake remained inversely associated with CRP and E-selectin. Multivariate-adjusted geometric means for women in the highest quintile of dietary magnesium intake were 24% lower for CRP (1.70 {+/-} 0.18 compared with 1.30 {+/-} 0.10 mg/dL; P for trend = 0.03) and 14% lower for E-selectin (48.5 {+/-} 1.84 compared with 41.9 {+/-} 1.58 ng/mL; P for trend = 0.01) than those for women in the lowest quintile. Conclusion:Magnesium intake from diet is modestly and inversely associated with some but not all markers of systematic inflammation and endothelial dysfunction in apparently healthy women. IS - 4 JF - Am J Clin Nutr EP - 1074 TI - Magnesium intake and plasma concentrations of markers of systemic inflammation and endothelial dysfunction in women VL - 85 SP - 1068 KW - dietary KW - endothelial KW - magnesium AU - Song, Yiqing AU - Li, Tricia AU - van Dam, Rob AU - Manson, Joann AU - Hu, Frank PY - 2007/04/01/ UR - http://www.ajcn.org/cgi/content/abstract/85/4/1068 ER -