Magnesium infusion and postoperative atrial fibrillation: a randomized clinical trial. Export

@article{citeulike:2295654, abstract = {BACKGROUND: Postoperative arrhythmias are among the most common complications of cardiac surgery. Total serum magnesium concentration will change after coronary bypass surgery but compensatory prophylactic administration of magnesium has remained a controversial issue. We studied whether prophylactic administration of magnesium could prevent post-coronary artery bypass grafting (CABG) arrhythmias and evaluated the effects of diabetes mellitus on prophylactic magnesium administration. METHODS: In a clinical trial, 345 consecutive CABG candidates were randomly assigned to study (n = 166, 48.1\%) and control groups. Patients in study group received supplemental magnesium infusion as following after induction of anesthesia until cardio-pulmonary bypass and then 8 g upon arrival in Intensive Care Unit (ICU) until 24 hr. Total serum magnesium concentration was measured at four designated time points: onset of induction, and 0, 24 and 48 hr after ICU admission. Cardiac arrhythmias were sought with a 12-lead electrocardiogram (ECG) from the end of surgery up till discharge. RESULTS: Atrial Fibrillation (Af) occurred in 34 patients (9.9\%). Total serum magnesium concentration was significantly higher in patients who received supplemental magnesium (P < 0.001) and significantly lower in Af patients (P= 0.02). Among non-diabetics, Af incidence was significantly lower in study group compared with control group. CONCLUSIONS: The occurrence of atrial fibrillation correlates with serum magnesium level. Diabetes mellitus probably hampers prophylactic effect of supplemental magnesium in preventing the occurrence of Af.}, address = {Tehran Heart Center, Medical Sciences/University of Tehran, Tehran, Iran. najafik@sina.tums.ac.ir}, author = {Najafi, M. and Hamidian, R. and Haghighat, B. and Fallah, N. and Tafti, H. A. and Karimi, A. and Boroumand, M. A.}, citeulike-article-id = {2295654}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/17694684}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=17694684}, journal = {Acta Anaesthesiol Taiwan}, keywords = {afli, cabg, cardiac, magnesium}, month = {June}, number = {2}, pages = {89--94}, posted-at = {2008-01-28 00:16:13}, priority = {2}, title = {Magnesium infusion and postoperative atrial fibrillation: a randomized clinical trial.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/17694684}, volume = {45}, year = {2007} }

TY - JOUR ID - citeulike:2295654 L3 - citeulike-article-id:2295654 N2 - BACKGROUND: Postoperative arrhythmias are among the most common complications of cardiac surgery. Total serum magnesium concentration will change after coronary bypass surgery but compensatory prophylactic administration of magnesium has remained a controversial issue. We studied whether prophylactic administration of magnesium could prevent post-coronary artery bypass grafting (CABG) arrhythmias and evaluated the effects of diabetes mellitus on prophylactic magnesium administration. METHODS: In a clinical trial, 345 consecutive CABG candidates were randomly assigned to study (n = 166, 48.1%) and control groups. Patients in study group received supplemental magnesium infusion as following after induction of anesthesia until cardio-pulmonary bypass and then 8 g upon arrival in Intensive Care Unit (ICU) until 24 hr. Total serum magnesium concentration was measured at four designated time points: onset of induction, and 0, 24 and 48 hr after ICU admission. Cardiac arrhythmias were sought with a 12-lead electrocardiogram (ECG) from the end of surgery up till discharge. RESULTS: Atrial Fibrillation (Af) occurred in 34 patients (9.9%). Total serum magnesium concentration was significantly higher in patients who received supplemental magnesium (P < 0.001) and significantly lower in Af patients (P= 0.02). Among non-diabetics, Af incidence was significantly lower in study group compared with control group. CONCLUSIONS: The occurrence of atrial fibrillation correlates with serum magnesium level. Diabetes mellitus probably hampers prophylactic effect of supplemental magnesium in preventing the occurrence of Af. IS - 2 JF - Acta Anaesthesiol Taiwan AD - Tehran Heart Center, Medical Sciences/University of Tehran, Tehran, Iran. najafik@sina.tums.ac.ir EP - 94 TI - Magnesium infusion and postoperative atrial fibrillation: a randomized clinical trial. VL - 45 SP - 89 KW - afli KW - cabg KW - cardiac KW - magnesium AU - Najafi, M AU - Hamidian, R AU - Haghighat, B AU - Fallah, N AU - Tafti, HA AU - Karimi, A AU - Boroumand, MA PY - 2007/06// UR - http://view.ncbi.nlm.nih.gov/pubmed/17694684 ER -