Scaled correlation analysis: a better way to compute a cross-correlogram.

When computing a cross-correlation histogram, slower signal components can hinder the detection of faster components, which are often in the research focus. For example, precise neuronal synchronization often co-occurs with slow co-variation in neuronal rate responses. Here we present a method - dubbed scaled correlation analysis - that enables the isolation of the cross-correlation histogram of fast signal components. The method computes correlations only on small temporal scales (i.e. on short segments of signals such as 25 ms), resulting in the removal of correlation components slower than those defined by the scale. Scaled correlation analysis has several advantages over traditional filtering approaches based on computations in the frequency domain. Among its other applications, as we show on data from cat visual cortex, the method can assist the studies of precise neuronal synchronization. © 2012 The Authors. European Journal of Neuroscience © 2012 Federation of European Neuroscience Societies and Blackwell Publishing Ltd.